Introduction: Carbamazepine (CBZ) is used for the treatment of epilepsy and other
neurological and psychiatric disorders. The occurrence of adverse reactions (ADRs) to CBZ …

Therapeutic drug monitoring (TDM) is a multi-disciplinary clinical specialty used for
optimization and individualization of drug therapy in the general and special populations …

Drug toxicity is frequently caused by electrophilic reactive metabolites that covalently bind to
proteins. Epoxides comprise a large class of three-membered cyclic ethers. These …

Objective To assess the efficacy and safety of eslicarbazepine acetate (ESL) as
monotherapy in North American patients with partial‐onset seizures (POS). Methods This …

Purpose Analysis of overall tolerability and neurological adverse effects (AEs) of
eslicarbazepine acetate (ESL), lacosamide (LCM) and oxcarbazepine (OXC) from double …

Despite the introduction of many second-generation antiepileptic drugs (AEDs) in the last 2
decades, the proportion of individuals with pharmaco-resistant epilepsy has not been …

Abstract Background Eslicarbazepine acetate (ESL, Aptiom®) is a once-daily (QD)
anticonvulsant, approved as adjunctive treatment of partial-onset seizures (POS). It is …

Eslicarbazepine acetate (ESL) is a new antiepileptic drug whose mechanism of action is
blockade of the voltage-gated sodium channel (VGSC). However, in respect to …

ABSTRACT INTRODUCTION Research into the pharmacologic management of bipolar type
I illness continues to progress. AREAS COVERED Randomized clinical trials performed with …

Epilepsy is a common neurological disorder. Despite a broad range of commonly used
antiepileptic drugs, approximately 30% of patients with epilepsy have drug resistance or …