The formation of advanced glycation end-products (AGE) in tissues is a physiological
process; however, excessive production and storage are pathological and lead to …

Chronic kidney disease (CKD) patients have a higher risk of developing early
cardiovascular disease (CVD). Although vascular calcification (VC) is one of the strongest …

Background and aims Vascular calcification (VC) is an intricate active process, significantly
controlled by vascular smooth muscle cells (VSMCs). Mitochondrial dysfunction plays a …

Vascular calcification (VC) describes the pathophysiological phenotype of calcium apatite
deposition within the vascular wall, leading to vascular stiffening and the loss of compliance …

Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality in the
world. Despite considerable progress in the diagnosis, treatment and prognosis of CVDs …

The age-old axiom that one is as old as his or her vessels are, calls for ongoing critical re-
examination of modifiable risk factors of accelerated vascular ageing in chronic kidney …

Background Vascular calcification associated with chronic kidney disease (CKD) can
increase the risk of mortality. Elevated serum levels of high mobility group box 1 (HMGB1) …

Patients with chronic kidney disease (CKD) have an elevated prevalence of atheromatous
(ATH) and/or non-atheromatous (non-ATH) cardiovascular disease (CVD) due to an array of …

In patients with advanced chronic kidney disease (CKD), the accumulation of uremic toxins,
caused by a combination of decreased excretion secondary to reduced kidney function and …

The interaction between gut microbiota and the host has gained widespread concern. Gut
microbiota not only provides nutrients from the ingested food but also generates bioactive …