[HTML][HTML] RNA-based therapeutics: an overview and prospectus

Y Zhu, L Zhu, X Wang, H Jin - Cell death & disease, 2022 - nature.com
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …

[HTML][HTML] The biological applications of DNA nanomaterials: current challenges and future directions

W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …

The delivery of therapeutic oligonucleotides

RL Juliano - Nucleic acids research, 2016 - academic.oup.com
The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …

Challenges and perspectives of DNA nanostructures in biomedicine

A Keller, V Linko - Angewandte Chemie International Edition, 2020 - Wiley Online Library
DNA nanotechnology holds substantial promise for future biomedical engineering and the
development of novel therapies and diagnostic assays. The subnanometer‐level …

DNA nanostructures: current challenges and opportunities for cellular delivery

A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …

Chemistry can make strict and fuzzy controls for bio-systems: DNA nanoarchitectonics and cell-macromolecular nanoarchitectonics

M Komiyama, K Yoshimoto, M Sisido… - Bulletin of the Chemical …, 2017 - academic.oup.com
In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA
nanoarchitectonics and cell-macromolecular nanoarchitectonics, both of which are basically …

Programmable and multifunctional DNA‐based materials for biomedical applications

Y Zhang, J Tu, D Wang, H Zhu, SK Maity… - Advanced …, 2018 - Wiley Online Library
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …

DNA nanostructures as smart drug-delivery vehicles and molecular devices

V Linko, A Ora, MA Kostiainen - Trends in biotechnology, 2015 - cell.com
DNA molecules can be assembled into custom predesigned shapes via hybridization of
sequence-complementary domains. The folded structures have high spatial addressability …

[HTML][HTML] DNA nanostructures at the interface with biology

KE Bujold, A Lacroix, HF Sleiman - Chem, 2018 - cell.com
Over the past four decades, the field of structural DNA nanotechnology has evolved into an
accessible approach to generating DNA nanostructures with precise control of size …

Aptamer-functionalized DNA origami for targeted codelivery of antisense oligonucleotides and doxorubicin to enhance therapy in drug-resistant cancer cells

Q Pan, C Nie, Y Hu, J Yi, C Liu, J Zhang… - … applied materials & …, 2019 - ACS Publications
Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To
overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for …