[HTML][HTML] RNA-based therapeutics: an overview and prospectus
Y Zhu, L Zhu, X Wang, H Jin - Cell death & disease, 2022 - nature.com
The growing understanding of RNA functions and their crucial roles in diseases promotes
the application of various RNAs to selectively function on hitherto “undruggable” proteins …
the application of various RNAs to selectively function on hitherto “undruggable” proteins …
[HTML][HTML] The biological applications of DNA nanomaterials: current challenges and future directions
W Ma, Y Zhan, Y Zhang, C Mao, X Xie… - Signal transduction and …, 2021 - nature.com
DNA, a genetic material, has been employed in different scientific directions for various
biological applications as driven by DNA nanotechnology in the past decades, including …
biological applications as driven by DNA nanotechnology in the past decades, including …
The delivery of therapeutic oligonucleotides
RL Juliano - Nucleic acids research, 2016 - academic.oup.com
The oligonucleotide therapeutics field has seen remarkable progress over the last few years
with the approval of the first antisense drug and with promising developments in late stage …
with the approval of the first antisense drug and with promising developments in late stage …
Challenges and perspectives of DNA nanostructures in biomedicine
DNA nanotechnology holds substantial promise for future biomedical engineering and the
development of novel therapies and diagnostic assays. The subnanometer‐level …
development of novel therapies and diagnostic assays. The subnanometer‐level …
DNA nanostructures: current challenges and opportunities for cellular delivery
A Lacroix, HF Sleiman - ACS nano, 2021 - ACS Publications
DNA nanotechnology has produced a wide range of self-assembled structures, offering
unmatched possibilities in terms of structural design. Because of their programmable …
unmatched possibilities in terms of structural design. Because of their programmable …
Chemistry can make strict and fuzzy controls for bio-systems: DNA nanoarchitectonics and cell-macromolecular nanoarchitectonics
M Komiyama, K Yoshimoto, M Sisido… - Bulletin of the Chemical …, 2017 - academic.oup.com
In this review, we introduce two kinds of bio-related nanoarchitectonics, DNA
nanoarchitectonics and cell-macromolecular nanoarchitectonics, both of which are basically …
nanoarchitectonics and cell-macromolecular nanoarchitectonics, both of which are basically …
Programmable and multifunctional DNA‐based materials for biomedical applications
DNA encodes the genetic information; recently, it has also become a key player in material
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
science. Given the specific Watson–Crick base‐pairing interactions between only four types …
DNA nanostructures as smart drug-delivery vehicles and molecular devices
V Linko, A Ora, MA Kostiainen - Trends in biotechnology, 2015 - cell.com
DNA molecules can be assembled into custom predesigned shapes via hybridization of
sequence-complementary domains. The folded structures have high spatial addressability …
sequence-complementary domains. The folded structures have high spatial addressability …
[HTML][HTML] DNA nanostructures at the interface with biology
Over the past four decades, the field of structural DNA nanotechnology has evolved into an
accessible approach to generating DNA nanostructures with precise control of size …
accessible approach to generating DNA nanostructures with precise control of size …
Aptamer-functionalized DNA origami for targeted codelivery of antisense oligonucleotides and doxorubicin to enhance therapy in drug-resistant cancer cells
Q Pan, C Nie, Y Hu, J Yi, C Liu, J Zhang… - … applied materials & …, 2019 - ACS Publications
Drug resistance is a major obstacle to the efficient therapy of drug-resistant cancer. To
overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for …
overcome this problem, we constructed a multifunctional DNA origami-based nanocarrier for …