Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

The role matrix metalloproteinases in the production of aortic aneurysm

SW Rabkin - Progress in molecular biology and translational …, 2017 - Elsevier
Matrix metalloproteinases (MMPs) have been implicated in the pathogenesis of aortic
aneurysm because the histology of thoracic aortic aneurysm (TAA) and abdominal aortic …

MicroRNA-21 blocks abdominal aortic aneurysm development and nicotine-augmented expansion

L Maegdefessel, J Azuma, R Toh, A Deng… - Science translational …, 2012 - science.org
Identification and treatment of abdominal aortic aneurysm (AAA) remains among the most
prominent challenges in vascular medicine. MicroRNAs are crucial regulators of …

Medical management of small abdominal aortic aneurysms

BT Baxter, MC Terrin, RL Dalman - Circulation, 2008 - Am Heart Assoc
Abdominal aortic aneurysm is a common condition that may be lethal when it is
unrecognized. Current guidelines suggest repair as the aneurysm diameter reaches 5.0 to …

[HTML][HTML] Smoking and the pathophysiology of peripheral artery disease

W Wang, T Zhao, K Geng, G Yuan, Y Chen… - Frontiers in …, 2021 - frontiersin.org
Smoking is one of the most important preventable factors causing peripheral artery disease
(PAD). The purpose of this review is to comprehensively analyze and summarize the …

[HTML][HTML] Tobacco smoking and the risk of abdominal aortic aneurysm: a systematic review and meta-analysis of prospective studies

D Aune, S Schlesinger, T Norat, E Riboli - Scientific reports, 2018 - nature.com
Several studies have found that smoking increases the risk of abdominal aortic aneurysm,
however, the strength of the association has differed between studies and data from cohort …

Understanding the effects of tobacco smoke on the pathogenesis of aortic aneurysm

PE Norman, JA Curci - Arteriosclerosis, thrombosis, and vascular …, 2013 - Am Heart Assoc
Aneurysmal arterial disease is a vascular degenerative condition that is distinct from
atherosclerotic and other occlusive arterial diseases. There is regionalization of the …

[PDF][PDF] Animal models in the research of abdominal aortic aneurysms development

N Patelis, D Moris, D Schizas, C Damaskos… - Physiological …, 2017 - researchgate.net
Abdominal aortic aneurysm (AAA) is a prevalent and potentially life threatening disease.
Many animal models have been developed to simulate the natural history of the disease or …

[HTML][HTML] Translating mouse models of abdominal aortic aneurysm to the translational needs of vascular surgery

A Busch, S Bleichert, N Ibrahim, M Wortmann… - JVS-vascular …, 2021 - Elsevier
Introduction Abdominal aortic aneurysm (AAA) is a condition that has considerable
socioeconomic impact and an eventual rupture is associated with high mortality and …

Opportunities in abdominal aortic aneurysm research: epidemiology, genetics, and pathophysiology

H Kuivaniemi, JR Elmore - Annals of vascular surgery, 2012 - Elsevier
Aortic aneurysms are a complex genetic disorder with known environmental risk factors such
as smoking. Along the length of the aorta, significant heterogeneity occurs in the distribution …