Hypoxia-inducible transcription factors (HIFs) facilitate cellular adaptations to low-oxygen
environments. However, it is increasingly recognised that HIFs may be activated in response …

Imbalances of iron homeostasis are associated with an adverse clinical outcome of
pulmonary hypertension (PH). Herein, we aimed to analyze the impact of iron deficiency (ID) …

Background: Diabetic retinopathy (DR) is indicated as a major cause of blindness in the
world. Emerging evidence supports the interaction of iron metabolism with diabetes …

Background Many nutrients have powerful immunomodulatory actions with the potential to
alter susceptibility to COVID-19 infection, progression to symptoms, likelihood of severe …

Background Increased iron availability modifies cardiorespiratory function in healthy
volunteers and improves exercise capacity and quality of life in patients with heart failure or …

Cardiovascular (CV) diseases are the major cause of death in industrialized countries. The
main function of the CV system is to deliver nutrients and oxygen to all tissues. During most …

As an emerging discipline, panvascular diseases are a set of vascular diseases with
atherosclerosis as the common pathogenic hallmark, which mostly affect vital organs like the …

BACKGROUND Anemia has been shown to be a risk factor for coronary artery disease
(CAD) and mortality, whereas the role of iron metabolism remains controversial. METHODS …

The interplay between iron and oxygen is longstanding and central to all aerobic life. Tight
regulation of these interactions including homeostatic regulation of iron utilization ensures …

Despite recent advances in Pulmonary Arterial Hypertension (PAH) treatment, this condition
is still characterized by an extremely poor prognosis. In this review, we discuss the use of …