Abstract The ppk20 (pickpocket 20) gene was identified from a two-step screen that was
aimed at identifying genes relevant to Drosophila iron and heme homeostasis. Initially, our …

This review highlights the current understanding of hypoxia-inducible factors (HIFs) role as
regulators of oxygen-dependent reactions and inducers of genes expression in human …

With ascent to high altitude, the reduction in the partial pressure of oxygen (PO₂) drives the
stabilization of the hypoxia-inducible factor (HIF) family. As the key cellular oxygen sensor …

It is believed that hypoxia-induced factor (HIF1) is the key mediator of oxygen metabolism. It
was first identified as a transcription factor activated in cells and tissues by lowering the …

Background: Increasing iron bioavailability attenuates hypoxic pulmonary vasoconstriction
in both lowlanders and Sherpa at high altitude. In contrast, the pulmonary vasculature of …

Iron is an essential component of haemoglobin which is responsible for carrying oxygen in
various parts of the body. Deficiency of iron causes anemia which can further result in many …

Résumé La vasoconstriction pulmonaire hypoxique (VPH) est un mécanisme réflexe unique
aux poumons: la baisse de pression alvéolaire en oxygène induit une vasoconstriction …

Introducere: Diagnosticul de trombembolism venos (TEV) asociat cu anemie este rar. Ar
trebui să existe un indice de suspiciune ridicat pentru TEV la pacienții anemici. Obiectiv …

Introducere: Diagnosticul de trombembolism venos (TEV) asociat cu anemie este rar. Ar
trebui să existe un indice de suspiciune ridicat pentru TEV la pacienții anemici. Obiectiv …

Resch and colleagues have executed a remarkable series of complex experiments to better
understand the effect of iron dynamics on cardiac allografts. 1 The major conclusion is that …