Spinal cord injury: molecular mechanisms and therapeutic interventions

X Hu, W Xu, Y Ren, Z Wang, X He, R Huang… - Signal transduction and …, 2023 - nature.com
Spinal cord injury (SCI) remains a severe condition with an extremely high disability rate.
The challenges of SCI repair include its complex pathological mechanisms and the …

Electrical stimulation for the treatment of spinal cord injuries: A review of the cellular and molecular mechanisms that drive functional improvements

RM Dorrian, CF Berryman, A Lauto… - Frontiers in Cellular …, 2023 - frontiersin.org
Spinal cord injury (SCI) is a devastating condition that causes severe loss of motor, sensory
and autonomic functions. Additionally, many individuals experience chronic neuropathic …

Pathophysiology and therapeutic approaches for spinal cord injury

R Lima, A Monteiro, AJ Salgado, S Monteiro… - International Journal of …, 2022 - mdpi.com
Spinal cord injury (SCI) is a disabling condition that disrupts motor, sensory, and autonomic
functions. Despite extensive research in the last decades, SCI continues to be a global …

A comprehensive look at the psychoneuroimmunoendocrinology of spinal cord injury and its progression: mechanisms and clinical opportunities

MA Ortega, O Fraile-Martinez, C García-Montero… - Military Medical …, 2023 - Springer
Spinal cord injury (SCI) is a devastating and disabling medical condition generally caused
by a traumatic event (primary injury). This initial trauma is accompanied by a set of biological …

Immune response after central nervous system injury

AFM Salvador, J Kipnis - Seminars in immunology, 2022 - Elsevier
Traumatic injuries of the central nervous system (CNS) affect millions of people worldwide,
and they can lead to severely damaging consequences such as permanent disability and …

Fibrotic scar after spinal cord injury: crosstalk with other cells, cellular origin, function, and mechanism

Z Li, S Yu, X Hu, Y Li, X You, D Tian… - Frontiers in cellular …, 2021 - frontiersin.org
The failure of axonal regeneration after spinal cord injury (SCI) results in permanent loss of
sensorimotor function. The persistent presence of scar tissue, mainly fibrotic scar and …

Regulatory role of mesenchymal stem cells on secondary inflammation in spinal cord injury

QM Pang, SY Chen, SP Fu, H Zhou… - Journal of …, 2022 - Taylor & Francis
Spinal cord injury (SCI) is a catastrophic condition with high morbidity and mortality that still
lacks effective therapeutic strategies. It is well known that the most important stage in SCI …

The leaky gut and the gut microbiome in sepsis–targets in research and treatment

W Chancharoenthana, S Kamolratanakul… - Clinical …, 2023 - portlandpress.com
Both a leaky gut (a barrier defect of the intestinal surface) and gut dysbiosis (a change in the
intestinal microbial population) are intrinsic to sepsis. While sepsis itself can cause …

The immune microenvironment and tissue engineering strategies for spinal cord regeneration

Y Feng, Y Peng, J Jie, Y Yang, P Yang - Frontiers in Cellular …, 2022 - frontiersin.org
Regeneration of neural tissue is limited following spinal cord injury (SCI). Successful
regeneration of injured nerves requires the intrinsic regenerative capability of the neurons …

An emerging role of inflammasomes in spinal cord injury and spinal cord tumor

J Chen, Y Shen, X Shao, W Wu - Frontiers in Immunology, 2023 - frontiersin.org
Spinal cord injury (SCI) and spinal cord tumor are devastating events causing structural and
functional impairment of the spinal cord and resulting in high morbidity and mortality; these …