Understanding the molecular mechanisms underlying liver fibrogenesis is fundamentally
relevant to developing new treatments that are independent of the underlying etiology. The …

The pulmonary vasculature has been frequently overlooked in acute and chronic lung
diseases, such as acute respiratory distress syndrome (ARDS), pulmonary fibrosis (PF), and …

BACKGROUND Uterine leiomyoma (also known as fibroid or myoma) is the most common
benign tumor of the uterus found in women of reproductive age. It is not usually fatal but can …

Oxidative stress, mainly contributed by reactive oxygen species (ROS), has been implicated
in pathogenesis of several diseases. We review two primary examples; fibrosis and cancer …

Fibrosis is increasingly appreciated as a major player in adipose tissue dysfunction. In
rapidly expanding adipose tissue, pervasive hypoxia leads to an induction of HIF1α that in …

Kidney fibrosis is a common histological manifestation of functional decline in the kidney.
Fibrosis is a reactive process that develops in response to excessive epithelial injury and …

Betulinic acid, a pentacyclic triterpene, is distributed in a variety of plants, such as birch,
eucalyptus and plane trees. It shows a wide spectrum of biological and pharmacological …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Fibroblasts, which are traditionally recognized as a quiescent cell responsible for
extracellular matrix production, are more and more appreciated as an active key player of …

Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …