Histone variants provide versatility in the basic unit of chromatin, helping to define dynamic
landscapes and cell fates. Maintaining genome integrity is paramount for the cell, and it is …

Histone variants, which generally differ in few amino acid residues, can replace core
histones (H1, H2A, H2B, and H3) to confer specific structural and functional features to …

Aortic dissection is a devastating cardiovascular disease with a high lethality. Histone
variants maintain the genomic integrity and play important roles in development and …

Our understanding of cancer genomes has allowed for the integration of molecular data into
histopathological classifications for routine stratification of patients. In the last 10–15 years …

Glutamine addiction is a significant hallmark of metabolic reprogramming in tumors and is
crucial to the progression of cancer. Nevertheless, the regulatory mechanisms of glutamine …

The centromere is a unique chromatin domain that links sister chromatids and forms the
attachment site for spindle microtubules in mitosis. Centromere inheritance is largely DNA …

Background Centromere protein L (CENPL) is associated with a variety of human diseases.
However, its function in breast cancer remains uncertain. Methods The Cancer Genome …

Specific localization of the histone H3 variant CENP-A at centromeres is key for faithful
chromosome segregation during cell division, with CENP-A mislocalization being …

Simple Summary Histone chaperones are responsible for histone metabolism. Recent
investigations have revealed that the abnormal expression of several histone chaperones in …

Background: Centromeric protein A (CENP-A), an essential protein involved in chromosomal
segregation during cell division, is associated with several cancer types. However, its role in …