Despite great international efforts, malaria still inflicts an enormous toll on human lives,
especially in Africa. Throughout history, antimalarial medicines have been one of the most …

Resistance to antimalarial drugs has often threatened malaria elimination efforts and
historically has led to the short-term resurgence of malaria incidences and deaths. With …

Background In 1993, Malawi became the first country in Africa to replace chloroquine with
the combination of sulfadoxine and pyrimethamine for the treatment of malaria. At that time …

Worldwide spread of Plasmodium falciparum drug resistance to conventional antimalarials,
chloroquine and sulfadoxine/pyrimethamine, has been imposing a serious public health …

Background An assessment of the correlation between anti-malarial treatment outcome and
molecular markers would improve the early detection and monitoring of drug resistance by …

There has been a relentless increase in resistance of malaria parasites to conventional
antimalarial drugs, including chloroquine, sulfadoxine–pyrimethamine and mefloquine.• In …

Efforts to control malaria worldwide have been hindered by the development and expansion
of parasite populations resistant to many first‐line antimalarial compounds. Two of the best …

Chloroquine (CQ) is an important antimalarial drug for the treatment of special patient
groups and as a comparator for preclinical testing of new drugs. Pharmacokinetic data for …

Malaria continues to be a leading cause of death in the tropics, taking the heaviest toll on
children in Africa, where drug resistant Plasmodium falciparum has led to rising malaria …

The naturally acquired microbiota of Anopheles can influence vector's susceptibility to
Plasmodium and its capacity to transmit them. Microbiota modification is a new challenge to …