Submucosal glands contribute to airway surface liquid (ASL), a film that protects all airway
surfaces. Glandular mucus comprises electrolytes, water, the gel-forming mucin MUC5B …

Malfunction of the cell surface glycoprotein, cystic fibrosis transmembrane conductance
regulator, is the molecular hallmark of cystic fibrosis (CF), causing salt imbalance across the …

Fluid and macromolecule secretion by submucosal glands in mammalian airways is
believed to be important in normal airway physiology and in the pathophysiology of cystic …

We all know one when we see one. A cystic fibrosis (CF) lung exacerbation is an ill-defined
entity recognized by physicians and patients with CF as a red flag indicating it is again time …

We are testing the hypothesis that the malfunctioning of airway gland serous cells is a
component of cystic fibrosis (CF) airway disease. CF is caused by mutations that disrupt CF …

Lactoferrin and lysozyme are important antimicrobial compounds of airway surface liquid,
derived predominantly from serous cells of submucosal glands but also from surface …

Study objectives Nasal polyps frequently appear in patients with cystic fibrosis (CF). The
aims of this study were to focus on what problems (symptoms, endoscopic findings, and …

Chloride channels play an important role in the physiology and pathophysiology of epithelia,
but their pharmacology is still poorly developed. We have chemically synthesized a series of …

Ferric enterobactin utilization by Bordetella bronchiseptica and Bordetella pertussis requires
the BfeA outer membrane receptor. Under iron-depleted growth conditions, transcription of …

Submucosal glands were isolated within 4 h of death from tracheae and bronchi obtained
from autopsied lungs, and the secretory response of secretory leukocyte protease inhibitor …