Histamine is a transmitter in the nervous system and a signaling molecule in the gut, the
skin, and the immune system. Histaminergic neurons in mammalian brain are located …

The zebrafish has become a widely used model organism because of its fecundity, its
morphological and physiological similarity to mammals, the existence of many genomic tools …

The zebrafish (Danio rerio) is emerging as a promising model organism for experimental
studies of stress and anxiety. Here we further validate zebrafish models of stress by …

One of the most commonly used behavioral endpoints measured in preclinical studies using
rodent models is thigmotaxis (or “wall-hugging”). Thigmotaxis is a well-validated index of …

Zebrafish are increasingly being used in behavioral neuroscience,
neuropsychopharmacology and neurotoxicology. Recently, behavioral screens used to …

The scototaxis (dark/light preference) protocol is a behavioral model for fish that is being
validated to assess the antianxiety effects of pharmacological agents and the behavioral …

Modulatory neurotransmitters which signal through G protein-coupled receptors control
brain functions which deteriorate in degenerative brain diseases. During the past decade …

Analysis of habituation is widely used to characterize animal cognitive phenotypes and their
modulation. Although zebrafish (Danio rerio) are increasingly utilized in neurobehavioral …

Anxiolytic effects of nicotine have been documented in studies with rodents and humans.
Understanding the neural basis of nicotine-induced anxiolysis can help both with …

Zebrafish are becoming more widely used to study neurobehavioral pharmacology. We
have developed a method to assess novel environment diving behavior of zebrafish as a …