Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

Among the myriad of intracellular signaling networks that govern the cardiac development
and pathogenesis, mitogen-activated protein kinases (MAPKs) are prominent players that …

Yellon, Derek M., and James M. Downey. Preconditioning the Myocardium: From Cellular
Physiology to Clinical Cardiology. Physiol Rev 83: 1113-1151, 2003; 10.1152/physrev …

Therapeutic strategies to protect the ischemic myocardium have been studied extensively.
Reperfusion is the definitive treatment for acute coronary syndromes, especially acute …

Although activation of protein kinase C (PKC) ε and mitogen-activated protein kinases
(MAPKs) are known to play crucial roles in the manifestation of cardioprotection, the spatial …

A RAPIDLY growing body of evidence indicates that volatile anesthetics protect myocardium
against reversible and irreversible ischemic injury. Identifying the mechanisms by which …

It has been assumed that all Gi-coupled receptors trigger the protective action of
preconditioning by means of an identical intracellular signaling pathway. To test this …

1. Ischemic preconditioning and its endpoints morphological protection, while on the other
hand caution should be used when extrapolating findings from short-Brief episodes of …

Adenosine, a purine nucleoside, is ubiquitous in the body, and is a critical component of
ATP. Its concentration jumps 100-fold during periods of oxygen depletion and ischemia …

Cardiovascular diseases cause more mortality and morbidity worldwide than any other
diseases. Although many intracellular signaling pathways influence cardiac physiology and …