[HTML][HTML] The oral-brain axis: can periodontal pathogens trigger the onset and progression of Alzheimer's disease?

R Li, J Wang, W Xiong, Y Luo, H Feng, H Zhou… - Frontiers in …, 2024 - frontiersin.org
Alzheimer's disease (AD) is the most prevalent form of dementia, characterized by a
progressive cognitive decline. Sporadic AD, accounting for more than 95% of cases, may …

[HTML][HTML] Association between microbiological risk factors and neurodegenerative disorders: An umbrella review of systematic reviews and meta-analyses

X Wang, D Jiang, T Li, X Zhang, R Wang, S Gao… - Frontiers in …, 2022 - frontiersin.org
The role of microbiological factors in the development of neurodegenerative diseases is
attracting increasing attention, while the relationship remains debated. This study aimed to …

Treponema denticola Induces Alzheimer-Like Tau Hyperphosphorylation by Activating Hippocampal Neuroinflammation in Mice

Z Tang, X Cheng, X Su, L Wu… - Journal of Dental …, 2022 - journals.sagepub.com
Alzheimer's disease (AD) is the most common type of dementia. Tau hyperphosphorylation
and amyloid β (Aβ) deposition are the key pathological hallmarks of AD. Recent studies …

[HTML][HTML] Treponema denticola Induces Neuronal Apoptosis by Promoting Amyloid-β Accumulation in Mice

L Wu, X Su, Z Tang, L Jian, H Zhu, X Cheng, H Wu - Pathogens, 2022 - mdpi.com
Background: Neuronal apoptosis is a major contributor to Alzheimer's disease (AD).
Periodontitis is a significant risk factor for AD. The periodontal pathogens Porphyromonas …

[HTML][HTML] Treponema denticola Has the Potential to Cause Neurodegeneration in the Midbrain via the Periodontal Route of Infection—Narrative Review

F Pisani, V Pisani, F Arcangeli, A Harding… - International Journal of …, 2023 - mdpi.com
Alzheimer's disease (AD) is a neurodegenerative disease and the most common example of
dementia. The neuropathological features of AD are the abnormal deposition of extracellular …

The Historical Development of the Pathological Changes in Alzheimer's Disease Based on Microbiology, Anatomy, and Physiology

HB Allen, RA Allen - Medical Research Archives, 2022 - esmed.org
The major pathological changes in Alzheimer's disease were found in hippocampal
specimens from Alzheimer disease patients. We contend that spirochetal bacteria that make …

The Presence and Impact of Bacteria and Biofilms in Chronic Skin and Systemic Diseases

HB Allen, RA Allen, K Kannan, L Fransko - Medical Research Archives, 2023 - esmed.org
This will be an overview of our studies on biofilms and the diseases with which they are
associated. Where possible, it will include the microbes that create these biofilms, their …

The Role of α-Sheet Structure in Bacterial and Mammalian Amyloidogenesis and its Implication in the Microbial Alzheimer's Disease Hypothesis

TS Prosswimmer - 2023 - search.proquest.com
Mammalian amyloidogenesis is implicated in over 50 diseases and its formation is typically
considered inherently pathological. Conversely, many bacteria utilize amyloid fibrils as a …

[HTML][HTML] Chronic Intraocular Leptospiral Infection Relying on Biofilm Formation inside the Vitreous Cavity Leads to Recurrent Uveitis in Horses

B Wollanke, H Gerhards - Focus on Bacterial Biofilms, 2022 - intechopen.com
Equine recurrent uveitis (ERU) is a disease known and feared for centuries, as it almost
always leads to blindness even with careful and meticulous conservative treatment of the …