Dopamine receptors are widely distributed within the brain where they play critical
modulator roles on motor functions, motivation and drive, as well as cognition. The …

Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent
life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

Genome-wide association studies (GWASs) have ushered in a new era of reproducible
discovery in psychiatric genetics. The field has now identified hundreds of common genetic …

Inhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The
communication-as well as the connectivity-between corticolimbic regions of the brain are …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …

Leveraging high-dimensional molecular datasets can help us develop mechanistic insight
into associations between genetic variants and complex traits. In this study, we integrated …

Midbrain dopaminergic neurons located in the substantia nigra and the ventral tegmental
area are the main source of dopamine in the brain. They send out projections to a variety of …

Dysregulated inflammatory responses and blood–brain barrier (BBB) dysfunction are
recognized as central factors in the development of psychiatric disorders. The present study …

In mammals, excitatory cortical neurons develop from the proliferative epithelium and
progenitor cells in the ventricular zone and subventricular zone, and migrate radially to the …