The purpose of this article is to review the status and limitations of anatomic tumor response
metrics including the World Health Organization (WHO) criteria, the Response Evaluation …

Since its introduction in the early nineties as a promising functional imaging technique in the
management of neoplastic disorders, FDG-PET, and subsequently FDG-PET/CT, has …

Purpose: To investigate the relationship of pembrolizumab pharmacokinetics (PK) and
overall survival (OS) in patients with advanced melanoma and non–small cell lung cancer …

Unlike chemotherapy, which acts directly on the tumor, cancer immunotherapies exert their
effects on the immune system and demonstrate new kinetics that involve building a cellular …

About 100 early-phase clinical trials and investigator-led studies of targeted antivascular
therapies—both anti-angiogenic and vascular-targeting agents—have reported data derived …

Purpose Abiraterone acetate (AA) is a standard of care for metastatic castration-resistant
prostate cancer (CRPC). Despite a large food effect, AA was administered under fasting …

Model-Based Prediction of Phase III Overall Survival in Colorectal Cancer on the Basis of Phase
II Tumor Dynamics Page 1 Model-Based Prediction of Phase III Overall Survival in Colorectal …

Background Afatinib is an oral, irreversible ErbB family blocker that has shown activity in
epidermal growth factor receptor (EGFR)-mutated lung cancer. We hypothesized that the …

Genetic variation influences the response of an individual to drug treatments. Understanding
this variation has the potential to make therapy safer and more effective by determining …

Response criteria represent the standard by which the efficacy of therapeutic agents is
determined in cancer trials. The most widely used criteria are based on the anatomic …