Mechanisms of oocyte aneuploidy associated with advanced maternal age

M Mikwar, AJ MacFarlane, F Marchetti - Mutation Research/Reviews in …, 2020 - Elsevier
It is well established that maternal age is associated with a rapid decline in the production of
healthy and high-quality oocytes resulting in reduced fertility in women older than 35 years …

Exploring the evidence for epigenetic regulation of environmental influences on child health across generations

CV Breton, R Landon, LG Kahn, MB Enlow… - Communications …, 2021 - nature.com
Environmental exposures, psychosocial stressors and nutrition are all potentially important
influences that may impact health outcomes directly or via interactions with the genome or …

Real-world menstrual cycle characteristics of more than 600,000 menstrual cycles

JR Bull, SP Rowland, EB Scherwitzl, R Scherwitzl… - NPJ digital …, 2019 - nature.com
The use of apps that record detailed menstrual cycle data presents a new opportunity to
study the menstrual cycle. The aim of this study is to describe menstrual cycle characteristics …

Role of oxidative stress, infection and inflammation in male infertility

A Agarwal, M Rana, E Qiu, H AlBunni, AD Bui… - Andrologia, 2018 - Wiley Online Library
Oxidative stress (OS), defined as an overabundance of reactive oxygen species (ROS) or a
deficiency of antioxidants, has been linked to sperm damage and male infertility. There are …

Ovarian ageing: the role of mitochondria in oocytes and follicles

P May-Panloup, L Boucret… - Human reproduction …, 2016 - academic.oup.com
BACKGROUND There is a great inter-individual variability of ovarian ageing, and almost
20% of patients consulting for infertility show signs of premature ovarian ageing. This …

The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

L Secomandi, M Borghesan, M Velarde… - Human reproduction …, 2022 - academic.oup.com
BACKGROUND Advanced maternal age is associated with decreased oocyte quantity and
quality as well as uterine and placental dysfunctions. These changes lead to infertility …

[图书][B] Principles of animal nutrition

G Wu - 2017 - taylorfrancis.com
Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications

MG Da Broi, VSI Giorgi, F Wang, DL Keefe… - Journal of assisted …, 2018 - Springer
An equilibrium needs to be established by the cellular and acellular components of the
ovarian follicle if developmental competence is to be acquired by the oocyte. Both cumulus …

Mitochondria in ovarian aging and reproductive longevity

JL Chiang, P Shukla, K Pagidas, NS Ahmed… - Ageing research …, 2020 - Elsevier
Mitochondrial dysfunction is one of the hallmarks of aging. Consistently mitochondrial DNA
(mtDNA) copy number and function decline with age in various tissues. There is increasing …

Advanced maternal age in IVF: still a challenge? The present and the future of its treatment

FM Ubaldi, D Cimadomo, A Vaiarelli… - Frontiers in …, 2019 - frontiersin.org
Advanced maternal age (AMA;> 35 year) is associated with a decline in both ovarian
reserve and oocyte competence. At present, no remedies are available to counteract the …