Primary ovarian insufficiency (POI) is a rare gynecological condition. This disease causes
menstrual disturbances, infertility, and various health problems. Historically, hormone …

Increasing evidence shows that melatonin protected against age-related mitochondrial
oxidative damage. However, the protective effects of melatonin against ovarian aging has …

The objective of this work was to determine the role of mitochondria in the loss of oocyte
quality with maternal aging. Our results show that mitochondrial DNA (mtDNA) copy number …

STUDY QUESTION Are the mean numbers of blastocysts obtained from sibling cohorts of
oocytes recruited after follicular phase and luteal phase stimulations (FPS and LPS) in the …

The recent tendency to delay pregnancy has increased the incidence of age-related
infertility, as female reproductive competence decreases with aging. Along with aging, a …

Oxidative stress has been recognized as one of the causal mediators of female infertility by
affecting the oocyte quality and early embryo development. Improving oxidative stress is …

For most infertile couples, in vitro fertilization (IVF) represents the only chance to conceive.
Given the limited success of IVF procedures, novel approaches are continuously tested with …

Reproductive aging is on the rise globally and inseparable from the entire aging process. An
extreme form of reproductive aging is premature ovarian insufficiency (POI), which to date …

It has been found that the quality of oocytes from obese women has been compromised and
subsequent embryos displayed arrested development. The compromised quality may be …

BACKGROUND The use of nuclear transfer (NT) has been proposed as a novel
reproductive treatment to overcome the transmission of maternally-inherited mitochondrial …