[HTML][HTML] EGFR Mutations in Head and Neck Squamous Cell Carcinoma
S Nair, JA Bonner, M Bredel - International Journal of Molecular Sciences, 2022 - mdpi.com
EGFR is a prototypical receptor tyrosine kinase that is overexpressed in multiple cancers
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …
including head and neck squamous cell carcinoma (HNSCC). The standard of care for …
Insulin-like growth factor (IGF) axis in cancerogenesis
A Kasprzak, W Kwasniewski, A Adamek… - … Research/Reviews in …, 2017 - Elsevier
Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …
carcinogenesis of several human tumors is based on numerous epidemiological and pre …
Design, synthesis and anticancer evaluation of thieno [2, 3-d] pyrimidine derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
Deregulation of many kinases is directly linked to cancer development and the tyrosine
kinase family is one of the most important targets in current cancer therapy regimens. In this …
kinase family is one of the most important targets in current cancer therapy regimens. In this …
[HTML][HTML] Precision medicine approaches to overcome resistance to therapy in head and neck cancers
S Ortiz-Cuaran, J Bouaoud, A Karabajakian… - Frontiers in …, 2021 - frontiersin.org
Head and neck squamous cell carcinoma (HNSCC) is the sixth most incident cancer
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …
worldwide. More than half of HNSCC patients experience locoregional or distant relapse to …
[HTML][HTML] Wnt/β-catenin signaling in oral carcinogenesis
M Reyes, T Flores, D Betancur… - International Journal of …, 2020 - mdpi.com
Oral carcinogenesis is a complex and multifactorial process that involves cumulative genetic
and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair …
and molecular alterations, leading to uncontrolled cell proliferation, impaired DNA repair …
[HTML][HTML] Design, synthesis, anticancer activity and molecular docking of new 1, 2, 3-triazole-based glycosides bearing 1, 3, 4-thiadiazolyl, indolyl and arylacetamide …
New 1, 3, 4-thiadiazole thioglycosides linked to a substituted arylidine system were
synthesized via heterocyclization via click 1, 3-dipolar cycloaddition. The click strategy was …
synthesized via heterocyclization via click 1, 3-dipolar cycloaddition. The click strategy was …
Expanding the foundation for personalized medicine: implications and challenges for dentistry
I Garcia, R Kuska… - Journal of dental research, 2013 - journals.sagepub.com
Personalized medicine aims to individualize care based on a person's unique genetic,
environmental, and clinical profile. Dentists and physicians have long recognized variations …
environmental, and clinical profile. Dentists and physicians have long recognized variations …
[HTML][HTML] Therapeutic potential of antibody-drug conjugate-based therapy in head and neck cancer: a systematic review
Simple Summary Head and neck cancer (HNC) is a complex and extremely heterogeneous
disease that includes a wide variety of cancer subtypes. Despite notable advances in …
disease that includes a wide variety of cancer subtypes. Despite notable advances in …
[HTML][HTML] Genetic variant rs10251977 (G>A) in EGFR-AS1 modulates the expression of EGFR isoforms A and D
S Dhamodharan, MM Rose, SR Chakkarappan… - Scientific Reports, 2021 - nature.com
Tyrosine kinase inhibitor is an effective chemo-therapeutic drug against tumors with
deregulated EGFR pathway. Recently, a genetic variant rs10251977 (G> A) in exon 20 of …
deregulated EGFR pathway. Recently, a genetic variant rs10251977 (G> A) in exon 20 of …
Design, synthesis and anticancer evaluation of new 4-anilinoquinoline-3-carbonitrile derivatives as dual EGFR/HER2 inhibitors and apoptosis inducers
M Zou, J Li, B Jin, M Wang, H Chen, Z Zhang… - Bioorganic …, 2021 - Elsevier
Dual targeting of EGFR/HER2 receptor is an attractive strategy for cancer therapy. Four
series of 4-anilinoquinoline-3-carbonitrile derivatives were designed and prepared by …
series of 4-anilinoquinoline-3-carbonitrile derivatives were designed and prepared by …