Cancer immunotherapy based on immune-checkpoint inhibition or adoptive cell therapy has
revolutionized cancer care. Nevertheless, a large proportion of patients do not benefit from …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

The heart is uniquely responsible for providing its own blood supply through the coronary
circulation. Regulation of coronary blood flow is quite complex and, after over 100 years of …

G protein-coupled receptors (GPCRs) are critical cellular sensors that mediate numerous
physiological processes. In the heart, multiple GPCRs are expressed on various cell types …

Adenosine is an endogenous nucleoside with a short half-life that regulates many
physiological functions involving the heart and cardiovascular system. Among the …

The influence of hyperhomocysteinemia (HHCy) on cardiovascular disease (CVD) remains
unclear. HHCy is associated with inflammation and atherosclerosis, and it is an independent …

VSMC s in resistance arteries and arterioles express a diverse array of KV channels with
members of the KV 1, KV 2 and KV 7 families being particularly important. Members of the …

Potassium channels importantly contribute to the regulation of vascular smooth muscle
(VSM) contraction and growth. They are the dominant ion conductance of the VSM cell …

Adenosine is an ubiquitous extracellular signaling molecule and plays a fundamental role in
the regulation of coronary microcirculation through activation of adenosine receptors (ARs) …

Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …