The implementation of clinical pharmacogenetics in daily practice is limited for various
reasons. Today, however, it is a discipline in full expansion. Accordingly, in the recent times …

Endovascular interventional is an important treatment method for intracranial aneurysms.
However, due to the risk of intracranial thrombosis, prophylactic use of antiplatelet drugs is …

Introduction y objectives Spontaneous coronary artery dissection (SCAD) is a rare cause of
acute coronary syndrome. Most patients are empirically treated with beta-blockers and …

Purpose P2Y12 receptor inhibitors are drugs that decrease the risk of stent thrombosis and
lower the long-term risk of non-stent-related myocardial infarction and stroke. They inhibit …

Background Clopidogrel is an inactive prodrug, it catalyzed into its active form by
Cytochrome 450 and Paraoxonase-1 (PON-1). polymorphisms of genes encoding these …

Background Clopidogrel is widely used to prevent and treat cardiovascular atherosclerosis
and thrombosis. However, disturbance in the expression and activity of liver cytochrome …

Donepezil and memantine are the most common drugs used for Alzheimer's disease. Their
low effectiveness could partly be explained by genetic factors. Thus, we aim to identify …

Antiplatelet therapy is the foundational treatment for the prevention and treatment of
coronary and cerebrovascular ischemic events in patients with coronary heart disease …

This study included 24 healthy volunteers who received a single 37.5 mg oral dose of
tramadol. We analyzed 18 polymorphisms within CYP2D6, CYP2B6, CYP3A, COMT …

Clopidogrel (CLOP) is widely used worldwide for cardiovascular complications. CLOP is
highly metabolized in the liver to its active metabolite by cytochrome P450 enzymes. Studies …