This review describes some approaches in the synthesis of conformationally restricted
nucleoside analogues. The focus is on the preparation of nucleosides as monomers …

In recent years modified oligonucleotides (oligos) have become an area of increased
research activity. These synthetic biopolymers have long been used as molecular probes to …

Protein arginine methyltransferase 5 (PRMT5) is a type II arginine methyltransferase that
catalyzes the post-translational symmetric dimethylation of protein substrates. PRMT5 plays …

Two bicyclic 2 '-deoxynucleoside analogues containing a saturated and an unsaturated
three-carbon 2 ', 4 '-linkage, respectively, have been synthesized using a ring-closing …

Typical nucleosides are initially obtained from the nucleic acids, DNA and RNA, by
enzymatic hydrolysis, and they are of great biological importance in metabolic pathways. 1 …

Methods are described for the total synthesis of bicyclic perhydrofuropyran nucleosides as N-
analogues of the naturally occurring malayamycin A. Formation of the N-nucleosides relied …

Total Synthesis and Structural Confirmation of Malayamycin A: A Novel Bicyclic C-Nucleoside
from Streptomyces malaysiensis | Organic Letters ACS ACS Publications C&EN CAS Find my …

The synthesis of novel 1 ', 2 '-aminomethylene bridged (6-aza-2-oxabicyclo [3.2. 0]
heptane)“azetidine” pyrimidine nucleosides and their transformations to the corresponding …

The practice of organic synthesis over the past century has witnessed periods of
monumental achievements, due in major part to the creativity and ingenuity of the …

We have earlier reported the synthesis and antisense properties of the conformationally
constrained oxetane-C and-T containing oligonucleotides, which have shown effective down …