Neurodegenerative diseases (NDs) are a class of heterogeneous diseases that includes
Alzheimer's disease, Parkinson's disease, Huntington's disease, and amyotrophic lateral …

Mitokines are signaling molecules that enable communication of local mitochondrial stress
to other mitochondria in distant cells and tissues. Among those molecules are FGF21 …

Objective To determine the effects of low-vs. high-intensity aerobic and resistance training
on motor and cognitive function, brain activation, brain structure, and neurochemical …

Parkinson's disease (PD) is a common age-related neurodegenerative disorder whose
pathogenesis is not completely understood. Mitochondrial dysfunction and increased …

As human life expectancy increases, cognitive decline and memory impairment threaten
independence and quality of life. Therefore, finding prevention and treatment strategies for …

Alzheimer's disease (AD) is a major cause of dementia in older adults and is fast becoming
a major societal and economic burden due to an increase in life expectancy. Age seems to …

Background Multicomponent physical exercise is the most recommended type of physical
intervention in older adults. Experimental data suggest the relevance of the muscle-brain …

Mitochondrial health is based on a delicate balance of specific mitochondrial functions (eg
metabolism, signaling, dynamics) that are impaired in neurodegenerative diseases …

Sarcopenia has an insidious start that can induce physical malfunction, raise the risk of falls,
disability, and mortality in the old, severely impair the aged persons' quality of life and …

It has been proven that physical exercise improves cognitive function and memory, has an
analgesic and antidepressant effect, and delays the aging of the brain and the development …