Transfer RNAs (tRNAs) have been historically viewed as non-dynamic adaptors that decode
the genetic code into proteins. Recent work has uncovered dynamic regulatory roles for …

Summary tRNA function is based on unique structures that enable mRNA decoding using
anticodon trinucleotides. These structures interact with specific aminoacyl-tRNA synthetases …

The role of tRNAs is best known as adapter components of translational machinery.
According to the central dogma of molecular biology, DNA is transcribed to RNA and in turn …

Abstract tRNA molecules contain dense, abundant modifications that affect tRNA structure,
stability, mRNA decoding and tsRNA formation. tRNA modifications and related enzymes …

Queuosine (Q) is a complex tRNA modification found in bacteria and eukaryotes at position
34 of four tRNAs with a GUN anticodon, and it regulates the translational efficiency and …

There is mounting evidence that ancestral life experiences and environment can influence
phenotypes in descendants. The parental environment regulates offspring phenotypes …

Converting genetic information into functional proteins is a complex, multi-step process, with
each step being tightly regulated to ensure the accuracy of translation, which is critical to …

Successful pathogens must be able to adapt to a multitude of stressors imposed by their
host. Acinetobacter baumannii has emerged as a major global health threat due to its …

Developing quantitative models of substrate specificity for RNA processing enzymes is a key
step toward understanding their biology and guiding applications in biotechnology and …

RNAs are central to protein synthesis, with ribosomal RNA, transfer RNAs and messenger
RNAs comprising the core components of the translation machinery. In addition to the four …