We have performed a systematic review to summarize current knowledge concerning factors
related to survival in ALS and to evaluate the implications of these data for clinical trials …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of motor
neurons, resulting in worsening weakness of voluntary muscles until death occurs from …

Background The El Escorial and the revised Airlie House diagnostic criteria for amyotrophic
lateral sclerosis (ALS) classify patients into categories reflecting different levels of diagnostic …

Introduction: Numerous methods for motor unit number estimation (MUNE) have been
developed. The objective of this article is to summarize and compare the major methods and …

The past decade has seen tremendous efforts in biomarker discovery and validation for
neurodegenerative diseases. The source and type of biomarkers has continued to grow for …

Motor unit number estimation (MUNE) was introduced in 1971 as a way of providing an
objective and meaningful estimate of axon loss in diseases affecting the motor system. Over …

Previous studies suggest that in amyotrophic lateral sclerosis (ALS) the abductor pollicis
brevis (APB) and first dorsal interosseous (FDI) are more severely involved than abductor …

Growing evidence from animal models and patients with amyotrophic lateral sclerosis (ALS)
suggests that distal axonal degeneration begins very early in this disease, long before …

Insights into the mechanisms of amyotrophic lateral sclerosis (ALS) have relied
predominantly on the study of postmortem tissue. Modern technology has improved the …

Loss of highly fractionated movement involving the thumb and index finger is an early
characteristic of hand dysfunction in many ALS patients. These movements are largely …