How and when should we monitor chimerism after allogeneic stem cell transplantation?

P Bader, D Niethammer, A Willasch… - Bone marrow …, 2005 - nature.com
Chimerism analysis has become an important tool for the peri-transplant surveillance of
engraftment. It offers the possibility to realize impending graft rejection and can serve as an …

[PDF][PDF] Increasing mixed chimerism is an important prognostic factor for unfavorable outcome in children with acute lymphoblastic leukemia after allogeneic stem-cell …

P Bader, H Kreyenberg, W Hoelle… - Journal of clinical …, 2004 - researchgate.net
Purpose We recently reported that children with acute leukemias who show increasing
mixed chimerism (MC) after allogeneic stem-cell transplantation have a significantly …

Is microchimerism a sign of imminent disease recurrence after allogeneic hematopoietic stem cell transplantation? A systematic review of the literature

AK Haugaard, J Kofoed, TN Masmas, HO Madsen… - Blood reviews, 2020 - Elsevier
Chimerism analysis following hematopoietic stem cell transplantation (HSCT) for leukemia is
routinely applied in parallel with quantification of minimal residual disease (MRD) to identify …

Leukemia lineage-specific chimerism analysis is a sensitive predictor of relapse in patients with acute myeloid leukemia and myelodysplastic syndrome after …

J Mattsson, M Uzunel, L Tammik, J Aschan, O Ringden - Leukemia, 2001 - nature.com
One of the major complications after allogeneic stem cell transplantation (SCT) in patients
with malignant disease is a high frequency of relapse. We have prospectively analyzed the …

Quantification of donor and recipient hemopoietic cells by real-time PCR of single nucleotide polymorphisms

F Maas, N Schaap, S Kolen, A Zoetbrood, I Buño… - Leukemia, 2003 - nature.com
Abstract Analysis of changes in recipient and donor hemopoietic cell origin is extremely
useful to monitor the effect of stem cell transplantation (SCT) and sequential adoptive …

Increasing mixed chimerism defines a high-risk group of childhood acute myelogenous leukemia patients after allogeneic stem cell transplantation where pre-emptive …

P Bader, H Kreyenberg, W Hoelle… - Bone marrow …, 2004 - nature.com
Children with leukemias and increasing mixed chimerism (increasing MC) after allogeneic
stem cell transplantation have the highest risk to relapse. Early immunological intervention …

[HTML][HTML] NCI first international workshop on the biology, prevention, and treatment of relapse after allogeneic hematopoietic stem cell transplantation: report from the …

N Kröger, U Bacher, P Bader, S Böttcher… - Biology of Blood and …, 2010 - Elsevier
Relapse has become the major cause of treatment failure after allogeneic stem cell
transplantation. Outcome of patients with clinical relapse after transplantation generally …

Treatment of graft failure with TNI‐based reconditioning and haploidentical stem cells in paediatric patients

HM Teltschik, F Heinzelmann, B Gruhn… - British journal of …, 2016 - Wiley Online Library
Graft failure is a life‐threatening complication after allogeneic haematopoietic stem cell
transplantation (HSCT). We report a cohort of 19 consecutive patients (median age: 8· 5 …

[HTML][HTML] Chimerism-based pre-emptive immunotherapy with fast withdrawal of immunosuppression and donor lymphocyte infusions after allogeneic stem cell …

B Horn, A Petrovic, J Wahlstrom, CC Dvorak… - Biology of Blood and …, 2015 - Elsevier
The presence of increasing host chimerism or persistent mixed chimerism (MC) after
hematopoietic stem cell transplantation for leukemia in children is a predictor of relapse. To …

Long-term follow-up of persisting mixed chimerism after partially T cell-depleted allogeneic stem cell transplantation

N Schaap, A Schattenberg, E Mensink, F Preijers… - Leukemia, 2002 - nature.com
Using red cell phenotyping (RCP) and/or cytogenetics (CYT) we identified 19 patients with
persisting mixed chimerism (MC) among 231 patients transplanted with partially T cell …