There is a broad consensus that multiple sclerosis (MS) represents more than an
inflammatory disease: it harbors several characteristic aspects of a classical …

The central nervous system (CNS) is under close surveillance by immune cells, which
mediate tissue homeostasis, protection, and repair. Conversely, in neuroinflammation …

Targeting membrane proteins could improve the efficacy of T cell–based immunotherapies.
To facilitate the identification of T cell targets, we developed a hybrid genetic screening …

Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …

We summarize recent work illuminating how cerebrospinal fluid (CSF) regulates brain
function. More than a protective fluid cushion and sink for waste, the CSF is an integral CNS …

Meninges that surround the CNS consist of an outer fibrous sheet of dura mater
(pachymeninx) that is also the inner periosteum of the skull. Underlying the dura are the …

The prognosis of malignant gliomas remains poor, with median survival fewer than 20
months and a 5-year survival rate merely 5%. Their primary location in the central nervous …

Originally hypothesized to function solely as immunologic responders within the central
nervous system (CNS), emerging evidence has revealed that microglia have more complex …

Neurological symptoms in SARS-CoV-2-infected patients have been reported, but their
cause remains unclear. In theory, the neurological symptoms observed after SARS-CoV-2 …

Peripheral inflammation, defined as inflammation that occurs outside the central nervous
system, is an age-related phenomenon that has been identified as a risk factor for …