Fungal cell wall organization and biosynthesis

SJ Free - Advances in genetics, 2013 - Elsevier
The composition and organization of the cell walls from Saccharomyces cerevisiae, Candida
albicans, Aspergillus fumigatus, Schizosaccharomyces pombe, Neurospora crassa, and …

Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis

TRT Dagenais, NP Keller - Clinical microbiology reviews, 2009 - Am Soc Microbiol
Aspergillus species are globally ubiquitous saprophytes found in a variety of ecological
niches. Almost 200 species of aspergilli have been identified, less than 20 of which are …

A molecular vision of fungal cell wall organization by functional genomics and solid-state NMR

A Chakraborty, LD Fernando, W Fang… - Nature …, 2021 - nature.com
Vast efforts have been devoted to the development of antifungal drugs targeting the cell wall,
but the supramolecular architecture of this carbohydrate-rich composite remains …

The cell wall: a carbohydrate armour for the fungal cell

JP Latgé - Molecular microbiology, 2007 - Wiley Online Library
The cell wall is composed of a polysaccharide‐based three‐dimensional network.
Considered for a long time as an inert exoskeleton, the cell wall is now seen as a dynamic …

Aspergillus fumigatus and related species

JA Sugui, KJ Kwon-Chung… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
The genus Aspergillus contains etiologic agents of aspergillosis. The clinical manifestations
of the disease range from allergic reaction to invasive pulmonary infection. Among the …

What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis

A Abad, JV Fernández-Molina, J Bikandi… - Revista iberoamericana …, 2010 - Elsevier
Aspergillus fumigatus is an opportunistic pathogen that causes 90% of invasive aspergillosis
(IA) due to Aspergillus genus, with a 50–95% mortality rate. It has been postulated that …

Potential targets for next generation antimicrobial glycoconjugate vaccines

F Micoli, P Costantino, R Adamo - FEMS microbiology reviews, 2018 - academic.oup.com
Cell surface carbohydrates have been proven optimal targets for vaccine development.
Conjugation of polysaccharides to a carrier protein triggers a T-cell-dependent immune …

Genome-scale metabolic modeling of Aspergillus fumigatus strains reveals growth dependencies on the lung microbiome

MH Mirhakkak, X Chen, Y Ni, T Heinekamp… - Nature …, 2023 - nature.com
Aspergillus fumigatus, an opportunistic human pathogen, frequently infects the lungs of
people with cystic fibrosis and is one of the most common causes of infectious-disease …

The Aspergillus fumigatus cell wall integrity signaling pathway: drug target, compensatory pathways, and virulence

V Valiante, J Macheleidt, M Föge… - Frontiers in …, 2015 - frontiersin.org
Aspergillus fumigatus is the most important airborne fungal pathogen, causing severe
infections with invasive growth in immunocompromised patients. The fungal cell wall (CW) …

The fungal cell wall as a target for the development of new antifungal therapies

JCG Cortés, MÁ Curto, VSD Carvalho, P Pérez… - Biotechnology …, 2019 - Elsevier
In the past three decades invasive mycoses have globally emerged as a persistent source of
healthcare-associated infections. The cell wall surrounding the fungal cell opposes the …