Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

There is an urgent and recognized need for an interprofessional collaborative approach to
support global action in addressing antimicrobial resistance (AMR). Antimicrobial …

The containment of the phenomenon of resistance towards antimicrobials is a priority,
especially in preserving molecules acting against Gram-negative pathogens, which …

Background Adequate antibiotic dosing may improve outcomes in critically ill patients but is
challenging due to altered and variable pharmacokinetics. To address this challenge …

Background Severe infections and multidrug-resistant pathogens are common in critically ill
patients. Antimicrobial stewardship (AMS) and therapeutic drug monitoring (TDM) are …

Background Antibiotic exposure is often inadequate in critically ill patients with severe
sepsis or septic shock and this is associated with worse outcomes. Despite markedly altered …

Background Pharmacokinetics (PK) is often used to optimize individualized dosing regimens
of some drugs. This study was conducted to determine views, knowledge, and practices of …

Introduction Antibiotic dosing in critically ill patients is challenging because their
pharmacokinetics (PK) are altered and may change rapidly with disease progression …

Background The importance of optimising antimicrobial therapy is highlighted in the hospital
intensive care unit (ICU) patients. But roles of ICU pharmacists are still in its infancy in …

Background Recent evidence highlights the need for an interdisciplinary approach to
antimicrobial stewardship (AMS). Nursing involvement in optimising antimicrobials in the …