It is widely accepted that there are two principal forms of cell death; namely, necrosis and
apoptosis. According to the classical view, necrosis is the major mechanism of …

Excessive death of cardiac myocytes leads to many cardiac diseases, including myocardial
infarction, arrhythmia, heart failure and sudden cardiac death. For the last several decades …

Transient receptor potential (TRP) proteins have been identified as cation channels that are
activated by agonist–receptor coupling and mediate various cellular functions. TRPC7, a …

BACKGROUND: Cell death constitutes one of the key events in biology. Historically,
apoptosis and necrosis have been considered to represent the 2 fundamental forms of cell …

Objectives.–The aim of the present study was to determine whether 3-hydroxy-3-
methylglutaryl coenzyme A reductase inhibitors (statins) have preventive effects on the …

Background and purpose: Progression of heart failure in hypertensive Dahl rats is
associated with cardiac remodeling and increased cardiomyocyte apoptosis. This study was …

The effects of aging on cardiovascular function and cardiac structure were determined in a
rat model recommended for gerontological studies. A cross-sectional analysis assessed …

Cardiac hypertrophy from pathological stimuli often proceeds to heart failure, whereas
cardiac hypertrophy from physiological stimuli does not. In this study, physiological …

We investigated how exercise training superimposed on chronic hypertension impacted left
ventricular remodeling. Cardiomyocyte hypertrophy, apoptosis, and proliferation in hearts …

The general purpose of this study was to test the effect of exercise training on the left
ventricular (LV) pressure-volume relationship (LV/PV) and apoptotic signaling markers in …