[HTML][HTML] Tumor angiogenesis: Current challenges and therapeutic opportunities

FH Al-Ostoot, S Salah, HA Khamees… - Cancer Treatment and …, 2021 - Elsevier
Angiogenesis plays an important role in the development of cancer since it allows for the
delivery of oxygen, nutrients, and growth factors as well as tumor dissemination to distant …

Spheroid culture as a tool for creating 3D complex tissues

E Fennema, N Rivron, J Rouwkema… - Trends in …, 2013 - cell.com
3D cell culture methods confer a high degree of clinical and biological relevance to in vitro
models. This is specifically the case with the spheroid culture, where a small aggregate of …

Elevated angiopoietin-2 level in patients with continuous-flow left ventricular assist devices leads to altered angiogenesis and is associated with higher nonsurgical …

CE Tabit, P Chen, GH Kim, SE Fedson, G Sayer… - Circulation, 2016 - Am Heart Assoc
Background: Nonsurgical bleeding is the most common adverse event in patients with
continuous-flow left ventricular assist devices (LVADs) and is caused by arteriovenous …

[HTML][HTML] The impact of spaceflight and simulated microgravity on cell adhesion

X Lin, K Zhang, D Wei, Y Tian, Y Gao, Z Chen… - International Journal of …, 2020 - mdpi.com
Microgravity induces a number of significant physiological changes in the cardiovascular,
nervous, immune systems, as well as the bone tissue of astronauts. Changes in cell …

DPSCs treated by TGF-β1 regulate angiogenic sprouting of three-dimensionally co-cultured HUVECs and DPSCs through VEGF-Ang-Tie2 signaling

Y Zhang, J Liu, T Zou, Y Qi, B Yi… - Stem Cell Research & …, 2021 - Springer
Background Maintaining the stability and maturation of blood vessels is of paramount
importance for the vessels to carry out their physiological function. Smooth muscle cells …

Recent advances and future applications of microfluidic live-cell microarrays

M Rothbauer, D Wartmann, V Charwat, P Ertl - Biotechnology advances, 2015 - Elsevier
Microfluidic live-cell microarrays show much promise as screening tools for biomedical
research because they could shed light on key biological processes such as cell signaling …

Topical application of hydroxysafflor yellow A accelerates the wound healing in streptozotocin induced T1DM rats

SQ Gao, C Chang, XQ Niu, LJ Li, Y Zhang… - European Journal of …, 2018 - Elsevier
To investigate the effects of Hydroxysafflor Yellow A (HSYA), which is derived from safflower,
on the proliferation, migration and angiogenesis of cells in vitro and its potential efficacy in …

Hydroxysafflor yellow A promotes angiogenesis via the angiopoietin 1/tie-2 signaling pathway

T Chen, N Chen, N Pang, L Xiao, Y Li, R Li… - Journal of Vascular …, 2017 - karger.com
Background: The flowers of Carthamus tinctorius L. are widely used in traditional Chinese
medicine to treat cerebrovascular and cardiovascular diseases. Hydroxysafflor yellow A …

[HTML][HTML] Macrophage-derived SHP-2 inhibits the metastasis of colorectal cancer via Tie2-PI3K signals

X Wu, S Guan, Y Lu, J Xue, X Yu, QI Zhang… - Oncology …, 2023 - ncbi.nlm.nih.gov
This research aimed to explore the influence of Src homology-2 containing protein tyrosine
phosphatase (SHP-2) on the functions of tyrosine kinase receptors with immunoglobulin and …

Leptin enhances endothelial cell differentiation and angiogenesis in murine embryonic stem cells

S Kurtovic, TT Ng, A Gupta, V Arumugaswami… - Microvascular …, 2015 - Elsevier
The metabolic regulation of leptin and its angiogenic effects have been well characterized in
adult mammals. However, the role of leptin in the differentiation of embryonic stem cells …