Discoveries made over the past 20 years highlight the importance of mRNA decay as a
means of modulating gene expression and thereby protein production. Up until recently …

The RNA‐binding protein HuR (human antigen R) associates with numerous transcripts,
coding and noncoding, and controls their splicing, localization, stability, and translation …

The cytoplasmic events that control mammalian gene expression, primarily mRNA stability
and translation, potently influence the cellular response to internal and external signals. The …

The human embryonic lethal abnormal vision-like protein, HuR, is a member of the Hu family
of RNA-binding proteins. Over the past decade, this ubiquitously expressed protein has …

Some mitochondrial long noncoding RNAs (lncRNAs) are encoded by nuclear DNA, but the
mechanisms that mediate their transport to mitochondria are poorly characterized. Using …

Cancer‐related gene expression programs are strongly influenced by posttranscriptional
mechanisms. The RNA‐binding protein HuR is highly abundant in many cancers. Numerous …

The control of eukaryotic gene expression occurs at multiple levels, from transcription to
messenger RNA processing, transport, localization, turnover, and translation. RNA-binding …

Abstract Background Circular RNAs (circRNAs), a subclass of non-coding RNAs, play
essential roles in tumorigenesis and aggressiveness. Our previous study has identified that …

The function of the vast majority of mammalian long noncoding (lnc) RNAs remains
unknown. Here, analysis of a highly abundant mammalian lncRNA, OIP5-AS1, known as …

Cell signaling mechanisms modulate gene expression in response to internal and external
stimuli. Cellular adaptation requires a precise and coordinated regulation of the transcription …