Autophagy is a conserved pathway that delivers cytoplasmic contents to the lysosome for
degradation. Here we consider its roles in neuronal health and disease. We review …

The remarkable plasticity of Schwann cells allows them to adopt the Remak (non-myelin)
and myelin phenotypes, which are specialized to meet the needs of small and large …

The glial cell of the peripheral nervous system (PNS), the Schwann cell (SC), counts among
the most multifaceted cells of the body. During development, SCs secure neuronal survival …

Schwann cells respond to nerve injury by cellular reprogramming that generates cells
specialized for promoting regeneration and repair. These repair cells clear redundant …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Autophagy is emerging as a core regulator of Central Nervous System (CNS) aging and
neurodegeneration. In the brain, it has mostly been studied in neurons, where the delivery of …

Axons are electrically excitable, cable-like neuronal processes that relay information
between neurons within the nervous system and between neurons and peripheral target …

Abstract Rationale: Autophagy in Schwann cells (SCs) is crucial for myelin debris
degradation and clearance following peripheral nerve injury (PNI). Nerve growth factor …

Ineffective myelin debris clearance is a major factor contributing to the poor regenerative
ability of the central nervous system. In stark contrast, rapid clearance of myelin debris from …

Although macroautophagy deficits are implicated across adult-onset neurodegenerative
diseases, we understand little about how the discrete, highly evolved cell types of the central …