A space‐dependent 'enzyme‐substrate'type probe based on 'carboxylesterase‐amide group'for ultrafast fluorescent imaging orthotopic hepatocellular carcinoma
Y Wen, N Jing, M Zhang, F Huo, Z Li… - Advanced Science, 2023 - Wiley Online Library
Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis
remains a significant challenge due to complex physical environment. Human …
remains a significant challenge due to complex physical environment. Human …
α‐Lactam Electrophiles for Covalent Chemical Biology
A Mahía, AE Kiib, M Nisavic… - Angewandte Chemie …, 2023 - Wiley Online Library
Electrophilic groups are one of the key pillars of contemporary chemical biology and
medicinal chemistry. For instance, 3‐membered N‐heterocyclic compounds—such as …
medicinal chemistry. For instance, 3‐membered N‐heterocyclic compounds—such as …
Regulation of carboxylesterases and its impact on pharmacokinetics and pharmacodynamics: an up-to-date review
ABSTRACT Introduction Carboxylesterase 1 (CES1) and carboxylesterase 2 (CES2) are
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
among the most abundant hydrolases in humans, catalyzing the metabolism of numerous …
Rationally Engineered hCES2A Near-Infrared Fluorogenic Substrate for Functional Imaging and High-Throughput Inhibitor Screening
Y Fan, T Zhang, Y Song, Z Sang, H Zeng, P Liu… - Analytical …, 2023 - ACS Publications
Human carboxylesterase 2A (hCES2A) is an important endoplasmic reticulum (ER)-resident
enzyme that is responsible for the hydrolytic metabolism or activation of numerous ester …
enzyme that is responsible for the hydrolytic metabolism or activation of numerous ester …
Emerging role of carboxylesterases in nonalcoholic fatty liver disease
J Liu, B Yao, L Gao, Y Zhang, S Huang… - Biochemical …, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a global public
health problem. Carboxylesterases (CESs), as potential influencing factors of NAFLD, are …
health problem. Carboxylesterases (CESs), as potential influencing factors of NAFLD, are …
Human carboxylesterase 1A plays a predominant role in the hydrolytic activation of remdesivir in humans
F Zhang, HX Li, TT Zhang, Y Xiong, HN Wang… - Chemico-Biological …, 2022 - Elsevier
Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …
Hormetic effects of EGC and EGCG on CES1 activity and its rescue from oxidative stress in rat liver S9
X Luo, F Lu, Z Yin, Z Zhou, Z Wang, H Zhang - Chemico-Biological …, 2023 - Elsevier
Abstract Carboxylesterase 1 (CES1) is a hydrolytic enzyme that plays an important role in
the activation or deactivation of many therapeutic agents, thus affecting their …
the activation or deactivation of many therapeutic agents, thus affecting their …
Monitoring antiviral active metabolite (N-hydroxycytidine) levels in plasma in presence of carboxylesterase-2 inhibitor verapamil using copper …
This study focuses on the determination of the active metabolite of molnupiravir (MOL), N-
hydroxycytidine (NHC), using a square wave voltammetric (SWV) method. Carboxylesterase …
hydroxycytidine (NHC), using a square wave voltammetric (SWV) method. Carboxylesterase …
In vitro inhibition of carboxylesterase 1 by Kava (Piper methysticum) Kavalactones
Kava refers to the extracts from the rhizome of the plant Piper methysticum which is of
particular significance to various indigenous cultures in the South Pacific region …
particular significance to various indigenous cultures in the South Pacific region …
Near-infrared fluorescent probe based on carboxylesterase 2 and viscosity cascade response for early diagnosis of thyroid cancer
W Luo, Q Diao, L Lv, T Li, P Ma, D Song - Sensors and Actuators B …, 2024 - Elsevier
Abstract Carboxylesterase 2 (CES2) plays a critical role in the metabolism of ester-and
amide-containing drugs and thus has an impact on drug efficacy and toxicity. This study …
amide-containing drugs and thus has an impact on drug efficacy and toxicity. This study …