Fast and selective fluorescence imaging for a biomarker to related‐disease diagnosis
remains a significant challenge due to complex physical environment. Human …

Nonalcoholic fatty liver disease (NAFLD) is increasingly recognized as a global public
health problem. Carboxylesterases (CESs), as potential influencing factors of NAFLD, are …

Human carboxylesterase 2A (hCES2A) is an important endoplasmic reticulum (ER)-resident
enzyme that is responsible for the hydrolytic metabolism or activation of numerous ester …

Aconitine (AC), which is the primary bioactive diterpene alkaloid derived from Aconitum L
plants, have attracted considerable interest due to its unique structural feature. Additionally …

Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in
hospitalized adults and pediatric patients. Upon administration, remdesivir can be readily …

Phthalate esters (PAEs), accompanied by phthalate monoesters as hydrolysis metabolites in
humans, have been widely used as plasticizers and exhibited disruptive effects on the …

Electrophilic groups are one of the key pillars of contemporary chemical biology and
medicinal chemistry. For instance, 3‐membered N‐heterocyclic compounds—such as …

This study focuses on the determination of the active metabolite of molnupiravir (MOL), N-
hydroxycytidine (NHC), using a square wave voltammetric (SWV) method. Carboxylesterase …

Abstract Carboxylesterase 1 (CES1) is a hydrolytic enzyme that plays an important role in
the activation or deactivation of many therapeutic agents, thus affecting their …

Abstract Carboxylesterase 2 (CES2) plays a critical role in the metabolism of ester-and
amide-containing drugs and thus has an impact on drug efficacy and toxicity. This study …