Increased blood cholesterol is an independent risk factor for atherosclerotic cardiovascular
disease. Cholesterol homeostasis in the body is controlled mainly by endogenous synthesis …

Cholesterol plays a vital role in the human body as a precursor of steroid hormones and bile
acids, in addition to providing structure to cell membranes. Whole body cholesterol …

Dyslipidemia is a commonly encountered clinical condition and is an important determinant
of cardiovascular disease. Although secondary factors play a role in clinical expression …

Background and aims Many patients treated with statins are considered statin-resistant
because they fail to achieve adequate reduction of low density lipoprotein cholesterol (LDL …

Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

Niemann–Pick C1-Like 1 (NPC1L1) is a polytopic transmembrane protein responsible for
dietary cholesterol and biliary cholesterol absorption. Consistent with its functions, NPC1L1 …

Membrane transporters enable efficient cellular metabolism, aid in nutrient sensing, and
have been associated with various diseases, such as obesity and cancer. Genome-scale …

This review integrates historical biochemical and modern genetic findings that underpin our
understanding of the low-density lipoprotein (LDL) dyslipidemias that bear on human …

Phytosterol intake is recommended as an adjunctive therapy for hypercholesterolemia, and
plant sterols/stanols can reduce cholesterol absorption at the intestinal lumen through the …

Niemann-Pick C1-like 1 (NPC1L1) is an essential protein for dietary cholesterol absorption.
Nonsynonymous (NS) variants of NPC1L1 in humans have been suggested to associate …