Liver fibrosis assessment: MR and US elastography
Elastography has emerged as a preferred non-invasive imaging technique for the clinical
assessment of liver fibrosis. Elastography methods provide liver stiffness measurement …
assessment of liver fibrosis. Elastography methods provide liver stiffness measurement …
MR elastography of liver: current status and future perspectives
Non-invasive evaluation of liver fibrosis has evolved over the last couple of decades.
Currently, elastography techniques are the most widely used non-invasive methods for …
Currently, elastography techniques are the most widely used non-invasive methods for …
[HTML][HTML] A randomized, double-blind, placebo-controlled phase IIa trial of efruxifermin for patients with compensated NASH cirrhosis
SA Harrison, PJ Ruane, B Freilich, G Neff, R Patil… - Jhep Reports, 2023 - Elsevier
Background & Aims Efruxifermin has shown clinical efficacy in patients with non-alcoholic
steatohepatitis (NASH) and F1–F3 fibrosis. The primary objective of the BALANCED Cohort …
steatohepatitis (NASH) and F1–F3 fibrosis. The primary objective of the BALANCED Cohort …
Three distinct stroma types in human pancreatic cancer identified by image analysis of fibroblast subpopulations and collagen
Y Ogawa, Y Masugi, T Abe, K Yamazaki, A Ueno… - Clinical Cancer …, 2021 - AACR
Purpose: Cancer-associated fibroblasts have emerged to be highly heterogenous and can
play multifaceted roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression …
play multifaceted roles in dictating pancreatic ductal adenocarcinoma (PDAC) progression …
[HTML][HTML] Animal models of fibrosis in nonalcoholic steatohepatitis: do they reflect human disease?
Nonalcoholic steatohepatitis (NASH) is one of the most common chronic liver diseases in
the world, yet no pharmacotherapies are available. The lack of translational animal models …
the world, yet no pharmacotherapies are available. The lack of translational animal models …
Automated quantification and architectural pattern detection of hepatic fibrosis in NAFLD
S Gawrieh, D Sethunath, OW Cummings… - Annals of diagnostic …, 2020 - Elsevier
Accurate detection and quantification of hepatic fibrosis remain essential for assessing the
severity of non-alcoholic fatty liver disease (NAFLD) and its response to therapy in clinical …
severity of non-alcoholic fatty liver disease (NAFLD) and its response to therapy in clinical …
[HTML][HTML] Application of digital pathology and machine learning in the liver, kidney and lung diseases
B Wu, G Moeckel - Journal of Pathology Informatics, 2023 - Elsevier
The development of rapid and accurate Whole Slide Imaging (WSI) has paved the way for
the application of Artificial Intelligence (AI) to digital pathology. The availability of WSI in the …
the application of Artificial Intelligence (AI) to digital pathology. The availability of WSI in the …
[HTML][HTML] Elastin is a key factor of tumor development in colorectal cancer
Background Colorectal cancer (CRC) is the most common cancer and a leading cause of
death worldwide. Extracellular matrix (ECM) proteins regulate tumor growth and …
death worldwide. Extracellular matrix (ECM) proteins regulate tumor growth and …
Liver fibrosis quantification
SK Venkatesh, MS Torbenson - Abdominal radiology, 2022 - Springer
Liver fibrosis (LF) is the wound healing response to chronic liver injury. LF is the endpoint of
chronic liver disease (CLD) regardless of etiology and the single most important determinant …
chronic liver disease (CLD) regardless of etiology and the single most important determinant …
Collagen proportionate area is an independent predictor of long‐term outcome in patients with non‐alcoholic fatty liver disease
E Buzzetti, A Hall, M Ekstedt… - Alimentary …, 2019 - Wiley Online Library
Background Collagen proportionate area (CPA) measurement is a technique that quantifies
fibrous tissue in liver biopsies by measuring the amount of collagen deposition as a …
fibrous tissue in liver biopsies by measuring the amount of collagen deposition as a …