Recent progress in photosensitizers for overcoming the challenges of photodynamic therapy: from molecular design to application
Photodynamic therapy (PDT), a therapeutic mode involving light triggering, has been
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …
recognized as an attractive oncotherapy treatment. However, nonnegligible challenges …
[HTML][HTML] Current challenges and opportunities of photodynamic therapy against cancer
RV Huis in 't Veld, J Heuts, S Ma, LJ Cruz… - Pharmaceutics, 2023 - mdpi.com
BACKGROUND: Photodynamic therapy (PDT) is an established, minimally invasive
treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are …
treatment for specific types of cancer. During PDT, reactive oxygen species (ROS) are …
[HTML][HTML] Light technology for efficient and effective photodynamic therapy: A critical review
Simple Summary Photodynamic therapy (PDT) is a promising treatment for cancerous
tumours in which light technologies play a crucial role. An attempt to answer a long-standing …
tumours in which light technologies play a crucial role. An attempt to answer a long-standing …
[HTML][HTML] Multifunctional phototheranostic nanomedicine for cancer imaging and treatment
Cancer, as one of the most life-threatening diseases, shows a high fatality rate around the
world. When improving the therapeutic efficacy of conventional cancer treatments …
world. When improving the therapeutic efficacy of conventional cancer treatments …
Recent advances in photonanomedicines for enhanced cancer photodynamic therapy
JJ Hu, Q Lei, XZ Zhang - Progress in Materials Science, 2020 - Elsevier
Nowadays, photodynamic therapy (PDT) that employs photosensitizers (PSs) to generate
cytotoxic species under light irradiation for selective destruction of neoplastic lesions has …
cytotoxic species under light irradiation for selective destruction of neoplastic lesions has …
Combinational strategy for high-performance cancer chemotherapy
SY Qin, YJ Cheng, Q Lei, AQ Zhang, XZ Zhang - Biomaterials, 2018 - Elsevier
The clinical outcomes of conventional mono-chemotherapy of cancers are usually far from
satisfactory due to some issues such as tumor heterogeneity and resistance to …
satisfactory due to some issues such as tumor heterogeneity and resistance to …
Research progress on tumor hypoxia-associative nanomedicine
XX Xu, SY Chen, NB Yi, X Li, SL Chen, Z Lei… - Journal of Controlled …, 2022 - Elsevier
Hypoxia at the solid tumor site is generally related to the unrestricted proliferation and
metabolism of cancerous cells, which can cause tumor metastasis and aggravate tumor …
metabolism of cancerous cells, which can cause tumor metastasis and aggravate tumor …
A paclitaxel prodrug activatable by irradiation in a hypoxic microenvironment
S Zhou, X Hu, R Xia, S Liu, Q Pei… - Angewandte Chemie …, 2020 - Wiley Online Library
The innate hypoxic microenvironment of most solid tumors has a major influence on tumor
growth, invasiveness, and distant metastasis. Here, a hypoxia‐activated self‐immolative …
growth, invasiveness, and distant metastasis. Here, a hypoxia‐activated self‐immolative …
[HTML][HTML] Fighting hypoxia to improve PDT
L Larue, B Myrzakhmetov, A Ben-Mihoub… - Pharmaceuticals, 2019 - mdpi.com
Photodynamic therapy (PDT) has drawn great interest in recent years mainly due to its low
side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for …
side effects and few drug resistances. Nevertheless, one of the issues of PDT is the need for …
Nanoparticle-based drug delivery systems for controllable photodynamic cancer therapy
Y Zheng, Z Li, H Chen, Y Gao - European Journal of Pharmaceutical …, 2020 - Elsevier
Compared with the traditional treatment, photodynamic therapy (PDT) in the treatment of
malignant tumors has the advantages of less damage to normal tissues, quick therapeutic …
malignant tumors has the advantages of less damage to normal tissues, quick therapeutic …