This Review explores the interplay between T cell activation and cell metabolism and
highlights how metabolites serve two pivotal functions in shaping the immune response …

Lysophosphatidic acid (LPA) is a simple phospholipid consisting of a phosphate group,
glycerol moiety, and only one hydrocarbon chain. Despite its simple chemical structure, LPA …

Lysophosphatidic acid (LPA) is a bioactive lipid which increases in concentration locally and
systemically across different cancer types. Yet, the exact mechanism (s) of how LPA affects …

Lysophosphatidic acid (LPA) is a bioactive lipid mediator that regulates a variety of cellular
functions such as cell proliferation, migration, survival, calcium mobilization, cytoskeletal …

The development of immune checkpoint blockade (ICB) therapies has been instrumental in
advancing the field of immunotherapy. Despite the prominence of these treatments, many …

Lysophosphatidic acid (LPA) is an endogenous bioactive lipid that is produced
extracellularly and signals to cells via cognate LPA receptors, which are G‐protein coupled …

Secreted autotaxin (ATX) promotes tumor progression by producing the pleiotropic lipid
mediator lysophosphatidic acid (LPA). In a recent Nature Cancer paper, Bhattacharyya et al …

Lysophosphatidic acid (LPA) is a phospholipid that displays potent signalling activities that
are regulated in both an autocrine and paracrine manner. It can be found both extra-and …

Understanding of the metabolic reprogramming has revolutionized our insights into tumor
progression and potential treatment. This review concentrates on the aberrant metabolic …

Systemic lupus erythematosus (SLE) is a prototypic systemic autoimmune disease
characterized by the production of various autoantibodies and deposition of immune …