Cysteine cathepsin protease activity is frequently dysregulated in the context of neoplastic
transformation. Increased activity and aberrant localization of proteases within the tumour …

Gallic acid, a predominant polyphenol, has been shown to inhibit carcinogenesis in animal
models and in vitro cancerous cell lines. The inhibitory effect of gallic acid on cancer cell …

Cathepsins were originally identified as proteases that act in the lysosome. Recent work has
uncovered nontraditional roles for cathepsins in the extracellular space as well as in the …

Cysteine cathepsins are highly upregulated in a wide variety of cancers by mechanisms
ranging from gene amplification to post-transcriptional modification. Their localization within …

Critical limb ischemia (CLI), the most severe form of peripheral artery disease, is
characterized by pain at rest and non-healing ulcers in the lower extremities. For patients …

Cysteine protease cathepsins have traditionally been considered as lysosome-restricted
proteases that mediate proteolysis of unwanted proteins. However, studies from the past …

Pro-angiogenic bone marrow (BM) cells include subsets of hematopoietic cells that provide
vascular support and endothelial progenitor cells (EPCs), which under certain permissive …

Sprouting angiogenesis is an invasive process that involves proteolytic activities required for
the degradation of the endothelial basement membrane, cell migration with removal of …

Cysteine cathepsins belong to the papain-like family C1 of clan CA cysteine peptidases.
These enzymes are ubiquitously expressed and exert their proteolytic activity mainly, but not …

Heart failure is a devastating condition, the progression of which culminates in a mismatch of
oxygen supply and demand, with limited options for treatment. Heart failure has several …