[PDF][PDF] Mechanisms of pathogen invasion into the central nervous system

MD Cain, H Salimi, MS Diamond, RS Klein - Neuron, 2019 - cell.com
CNS infections continue to rise in incidence in conjunction with increases in
immunocompromised populations or conditions that contribute to the emergence of …

More than just protein degradation: The regulatory roles and moonlighting functions of extracellular proteases produced by fungi pathogenic for humans

D Satala, G Bras, A Kozik, M Rapala-Kozik… - Journal of Fungi, 2023 - mdpi.com
Extracellular proteases belong to the main virulence factors of pathogenic fungi. Their
proteolytic activities plays a crucial role in the acquisition of nutrients from the external …

Diversity, multifaceted evolution, and facultative saprotrophism in the European Batrachochytrium salamandrivorans epidemic

M Kelly, F Pasmans, JF Muñoz, TP Shea… - Nature …, 2021 - nature.com
While emerging fungi threaten global biodiversity, the paucity of fungal genome assemblies
impedes thoroughly characterizing epidemics and developing effective mitigation strategies …

Presence of low virulence chytrid fungi could protect European amphibians from more deadly strains

MS Greener, E Verbrugghe, M Kelly, M Blooi… - Nature …, 2020 - nature.com
Wildlife diseases are contributing to the current Earth's sixth mass extinction; one disease,
chytridiomycosis, has caused mass amphibian die-offs. While global spread of a …

Dangerous Liaisons: Interactions of Cryptococcus neoformans with Host Phagocytes

EA Gaylord, HL Choy, TL Doering - Pathogens, 2020 - mdpi.com
Cryptococcus neoformans is an opportunistic fungal pathogen and a leading cause of death
in immunocompromised individuals. The interactions of this yeast with host phagocytes are …

[PDF][PDF] Mycoparasites, gut dwellers, and saprotrophs: phylogenomic reconstructions and comparative analyses of Kickxellomycotina fungi

NK Reynolds, JE Stajich, GL Benny… - Genome biology and …, 2023 - academic.oup.com
Improved sequencing technologies have profoundly altered global views of fungal diversity
and evolution. High-throughput sequencing methods are critical for studying fungi due to the …

How environmental fungi cause a range of clinical outcomes in susceptible hosts

ST Denham, MA Wambaugh, JCS Brown - Journal of molecular biology, 2019 - Elsevier
Environmental fungi are globally ubiquitous and human exposure is near universal.
However, relatively few fungal species are capable of infecting humans, and among fungi …

Target-and prodrug-based design for fungal diseases and cancer-associated fungal infections

N Liu, J Tu, Y Huang, W Yang, Q Wang, Z Li… - Advanced Drug Delivery …, 2023 - Elsevier
Invasive fungal infections (IFIs) are emerging as a serious threat to public health and are
associated with high incidence and mortality. IFIs also represent a frequent complication in …

The possible role of microbial proteases in facilitating SARS-CoV-2 brain invasion

N Mjokane, OS Folorunso, AO Ogundeji, OM Sebolai - Biology, 2021 - mdpi.com
Simple Summary There is limited information on how SARS-CoV-2 reaches the brain. Thus,
this paper examines how, during co-infection, a protease-secreting microbe may facilitate …

Cerebrospinal fluid: a target of some fungi and an overview

D Corrêa-Moreira, R Castro, GL da Costa… - Memórias do Instituto …, 2023 - SciELO Brasil
Meningitis is a potentially life-threatening infection characterised by the inflammation of the
leptomeningeal membranes. The estimated annual prevalence of 8.7 million cases globally …