Profound immunomodulatory effects of 225Ac-NM600 drive enhanced anti-tumor response in prostate cancer

CA Ferreira, HK Potluri, C Massey, JJ Grudzinski… - bioRxiv, 2022 - biorxiv.org
An immunosuppressive tumor microenvironment has hampered the efficacy of
immunotherapy in prostate cancer. However, radiation-induced immunological effects can …

Quantification of internal dosimetry in PET patients II: Individualized Monte Carlo‐based dosimetry for [18F] fluorocholine PET

S Neira, J Guiu‐Souto, P Pais… - Medical …, 2021 - Wiley Online Library
Purpose To obtain individualized internal doses with a Monte Carlo (MC) method in patients
undergoing diagnostic [18F] FCH‐PET studies and to compare such doses with the MIRD …

Validation of Monte Carlo 131I radiopharmaceutical dosimetry workflow using a 3D‐printed anthropomorphic head and neck phantom

DP Adam, JJ Grudzinski, I Bormett, BL Cox… - Medical …, 2022 - Wiley Online Library
Purpose Approximately 50% of head and neck cancer (HNC) patients will experience loco‐
regional disease recurrence following initial courses of therapy. Retreatment with external …

Pretreatment CLR 124 positron emission tomography accurately predicts CLR 131 three-dimensional dosimetry in a triple-negative breast cancer patient

AE Besemer, JJ Grudzinski, JP Weichert… - Cancer Biotherapy & …, 2019 - liebertpub.com
Introduction: CLR1404 is a theranostic molecular agent that can be radiolabeled with 124I
(CLR 124) for positron emission tomography (PET) imaging, or 131I (CLR 131) for single …

Voxel-Level Dosimetry for Combined Iodine 131 Radiopharmaceutical Therapy and External Beam Radiation Therapy Treatment Paradigms for Head and Neck …

DP Adam, JJ Grudzinski, IR Marsh, PM Hill… - International Journal of …, 2024 - Elsevier
Purpose Targeted radiopharmaceutical therapy (RPT) in combination with external beam
radiation therapy (EBRT) shows promise as a method to increase tumor control and mitigate …

Radiobiology and radiation dosimetry in nuclear medicine

M Salvatori, M Cremonesi, L Indovina… - Nuclear Oncology: From …, 2022 - Springer
Radionuclide therapy (RNT) uses systemically administered radiopharmaceuticals directed
to a specific cancer-associated target to provide low-dose rate (LDR) treatment. The …

Monte Carlo techniques in nuclear medicine dosimetry

H Zaidi, P Andreo - Monte Carlo Calculations in Nuclear Medicine …, 2022 - iopscience.iop.org
In this chapter, the framework for the application of the Monte Carlo method to a wide range
of problems in nuclear medicine dosimetry is introduced. It also presents an introductory …

Creation of waterproof, TLD probes for dose measurements to validate image-based radiopharmaceutical therapy dosimetry workflow

DP Adam, C Hammer, JZ Malyshev… - Biomedical physics …, 2023 - iopscience.iop.org
Voxel-level dosimetry based on nuclear medicine images offers patient-specific
personalization of radiopharmaceutical therapy (RPT) treatments. Clinical evidence is …

Monte Carlo in Internal Dosimetry

HK Patni, DK Akar - Handbook on Radiation Environment, Volume 2: Dose …, 2024 - Springer
In internal dosimetry, the Monte Carlo technique is used for radiation transport to compute
values of efficiency of monitoring systems and energy deposition in various organs followed …

Absorbed dose of 18F-FDG for female patients: Monte Carlo versus MIRD method

AO Ezzati, F Mohajeri - The European Physical Journal Plus, 2023 - epjplus.epj.org
To estimate the absorbed dose of patients undergoing diagnostic PET with [18F] FDG by
using the MIRD and MC methods, a female patient phantom was considered. The organ …