Theranostic-targeted radionuclide therapies (TRT) and immunotherapies are two growing
categories of cancer treatments. While each of these has been employed in the treatment of …

Radiopharmaceutical therapies (RPT) activate a type I interferon (IFN1) response in tumor
cells. We hypothesized that the timing and amplitude of this response varies by isotope. We …

Fifty percent of all cancer patients receive radiation therapy as a component of treatment.
Radiation can immunomodulate the tumor microenvironment through a variety of …

Pharmacokinetic modeling of the radiopharmaceuticals used in molecular radiotherapy is an
important step towards accurate radiation dosimetry of such therapies. In this paper, we …

Combination radiopharmaceutical and external beam radiotherapy offers the potential to
diminish locoregional toxicity that remains dose-limiting in the conventional treatment …

Targeted radiopharmaceutical therapy (TRT) involving systemic administration of a tumor-
selective agent labeled with a radionuclide has demonstrated considerable promise for …

Nowadays, nuclear medicine procedures have become a standard for several pathologies,
both for diagnosis and therapeutic purposes. Also, regarding therapeutic applications, the …

Abstract [eng] Polymer gel dosimeters are a unique type of dosimeter that allow for three-
dimensional assessment of radiation dose distributions. These dosimeters are based on …

Targeted radionuclide therapy (TRT) is an effective treatment for metastatic prostate cancer.
This thesis develops a convolution-based dosimetric method for TRT and validates its …

In this chapter, RAPID, which stands for Radiopharmaceutical Assessment Platform for
Internal Dosimetry is introduced. The essential parts of the framework include: imaging …