Alzheimer's disease (AD) is the most prevalent neurodegenerative disease in ageing,
affecting around 46 million people worldwide but few treatments are currently available. The …

Cognitive abilities are important predictors of educational and occupational performance,
socioeconomic attainment, health, and longevity. Declines in cognitive abilities are linked to …

Background: Uncertainties persist about the associations of diabetes with risk of cognitive
impairment and dementia. We aimed to illuminate these associations from various aspects …

Background Parallel to growth of aging and obese populations, the prevalence of metabolic
diseases is rising. How body mass index (BMI) relates to frailty and mortality across frailty …

Alzheimer disease (AD) is the most common type of dementia, and is currently incurable;
existing treatments for AD produce only a modest amelioration of symptoms. Research into …

Controversies persist regarding the association between blood pressure (BP) and the risks
of cognitive impairment and dementia due to inconsistent definitions of BP exposure and …

Background—Age-related dementia, most commonly caused by Alzheimer disease or
cerebrovascular factors (vascular dementia), is a major public health threat. Chronic arterial …

Background Alcohol use has been identified as a risk factor for dementia and cognitive
decline. However, some patterns of drinking have been associated with beneficial effects …

There is growing evidence that loneliness is associated with mild cognitive impairment (MCI)
and dementia. However, the extent of this association remains unclear. A systematic review …

Identification of modifiable risk factors provides a crucial approach to the prevention of
dementia. Nutritional or nutrient-dependent risk factors are especially important because …