Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

[HTML][HTML] Anticancer activities of TCM and their active components against tumor metastasis

K Wang, Q Chen, Y Shao, S Yin, C Liu, Y Liu… - Biomedicine & …, 2021 - Elsevier
Abstract Traditional Chinese Medicine (TCM) has the characteristics of multiple targets,
slight side effects and good therapeutic effects. Good anti-tumor effects are shown by …

Potential role of flavonoids in treating chronic inflammatory diseases with a special focus on the anti-inflammatory activity of apigenin

R Ginwala, R Bhavsar, DGI Chigbu, P Jain, ZK Khan - Antioxidants, 2019 - mdpi.com
Inflammation has been reported to be intimately linked to the development or worsening of
several non-infectious diseases. A number of chronic conditions such as cancer, diabetes …

Therapeutic potential of flavonoids in pain and inflammation: mechanisms of action, pre-clinical and clinical data, and pharmaceutical development

CR Ferraz, TT Carvalho, MF Manchope, NA Artero… - Molecules, 2020 - mdpi.com
Pathological pain can be initiated after inflammation and/or peripheral nerve injury. It is a
consequence of the pathological functioning of the nervous system rather than only a …

Luteolin and its derivative apigenin suppress the inducible PD-L1 expression to improve anti-tumor immunity in KRAS-mutant lung cancer

ZB Jiang, WJ Wang, C Xu, YJ Xie, XR Wang, YZ Zhang… - Cancer letters, 2021 - Elsevier
Upregulated expression of immune checkpoint molecules correlates with exhausted
phenotype and impaired function of cytotoxic T cells to evade host immunity. By disrupting …

Formaldehyde-free synthesis of fully bio-based multifunctional bisbenzoxazine resins from natural renewable starting materials

MG Mohamed, CJ Li, MAR Khan, CC Liaw… - …, 2022 - ACS Publications
Although bio-based benzoxazines (BZs) have been explored widely as sustainable
thermosetting resins, few high-performance BZs have been prepared completely from …

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

OC Ugbogu, O Emmanuel, GO Agi, C Ibe, CN Ekweogu… - Heliyon, 2021 - cell.com
In traditional medicine, Ocimum gratissimum (clove basil) is used in the treatment of various
diseases such as diabetes, cancer, inflammation, anaemia, diarrhoea, pains, and fungal and …

Dietary polyphenols in chemoprevention and synergistic effect in cancer: Clinical evidences and molecular mechanisms of action

S Patra, B Pradhan, R Nayak, C Behera, S Das… - Phytomedicine, 2021 - Elsevier
Background Epidemiological studies has revealed that a diet rich in fruits and vegetables
could lower the risk of certain cancers. In this setting, natural polyphenols are potent …

Functionality of apigenin as a potent antioxidant with emphasis on bioavailability, metabolism, action mechanism and in vitro and in vivo studies: A review

P Kashyap, D Shikha, M Thakur… - Journal of food …, 2022 - Wiley Online Library
Numerous diseases such as cancer, diabetes, cardiovascular, neurodegenerative diseases,
etc. are linked with overproduction of reactive oxygen species (ROS) and oxidative stress …

The NRF2, thioredoxin, and glutathione system in tumorigenesis and anticancer therapies

M Jaganjac, L Milkovic, SB Sunjic, N Zarkovic - Antioxidants, 2020 - mdpi.com
Cancer remains an elusive, highly complex disease and a global burden. Constant change
by acquired mutations and metabolic reprogramming contribute to the high inter-and …