[HTML][HTML] Immunometabolic factors contributing to obesity-linked hepatocellular carcinoma

MG Akl, SB Widenmaier - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is a major public health concern that is promoted by
obesity and associated liver complications. Onset and progression of HCC in obesity is a …

siRNA-mediated gene silencing for non-alcoholic fatty liver disease: A comprehensive review of molecular targets

A Mahmoudi, M Rostami, MM Hajihasani… - European Polymer …, 2024 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning global public health distress, with
an estimated 25% of the world population affected. Despite the increasing prevalence and …

[HTML][HTML] Resmetirom ameliorates NASH-model mice by suppressing STAT3 and NF-κB signaling pathways in an RGS5-dependent manner

X Wang, L Wang, L Geng, N Tanaka, B Ye - International Journal of …, 2023 - mdpi.com
Resmetirom, a liver-directed, orally active agonist of THR-β, could play a favorable role in
treating NASH, but little is known about the underlying mechanism. A NASH cell model was …

[HTML][HTML] Huangqin decoction alleviates lipid metabolism disorders and insulin resistance in nonalcoholic fatty liver disease by triggering Sirt1/NF-κB pathway

BF Yan, LF Pan, YF Quan, Q Sha… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological entity
characterized by intrahepatic ectopic steatosis. As a consequence of increased consumption …

[HTML][HTML] Metabolic dysfunction-associated steatotic liver disease: An opportunity for collaboration between cardiology and hepatology

P Raggi, J Milic, M Manicardi, F Cinque, MG Swain… - Atherosclerosis, 2024 - Elsevier
Altered metabolic function has many detrimental effects on the body that can manifest as
cardiovascular and liver diseases. Traditional approaches to understanding and treating …

[HTML][HTML] Esculeogenin A, a Glycan from Tomato, Alleviates Nonalcoholic Fatty Liver Disease in Rats through Hypolipidemic, Antioxidant, and Anti-Inflammatory Effects

JM Al Jadani, NA Albadr, GM Alshammari, SA Almasri… - Nutrients, 2023 - mdpi.com
This study examined the preventative effects of esculeogenin A (ESGA), a newly discovered
glycan from tomato, on liver damage and hepatic steatosis in high-fat-diet (HFD)-fed male …

Analysis of the therapeutic potential of miR-124 and miR-16 in non-alcoholic fatty liver disease

A Mahmoudi, A Jalili, SH Aghaee-Bakhtiari… - Journal of Diabetes and …, 2024 - Elsevier
Backgrounds Non-alcoholic fatty liver disease (NAFLD) is a common condition affecting>
25% of the population worldwide. This disorder ranges in severity from simple steatosis (fat …

[HTML][HTML] Fenofibrate alleviates NAFLD by enhancing the PPARα/PGC-1α signaling pathway coupling mitochondrial function

X Wang, J Wang, C Ying, Y Xing, X Su… - BMC Pharmacology and …, 2024 - Springer
Background To comprehend the influences of fenofibrate on hepatic lipid accumulation and
mitochondrial function-related signaling pathways in mice with non-alcoholic fatty liver …

[HTML][HTML] Capparis spinosa improves non-alcoholic steatohepatitis through down-regulating SREBP-1c and a PPARα-independent pathway in high-fat diet-fed rats

R Akbari, H Yaghooti, MT Jalali, LS Khorsandi… - BMC research …, 2022 - Springer
Objective Non-alcoholic steatohepatitis (NASH) has become a global medical problem.
Currently, there is no approved pharmacologic treatment for this condition. Previous studies …

Current and experimental pharmacotherapy for the management of non-alcoholic fatty liver disease

A Katsarou, G Tsioulos, E Kassi, A Chatzigeorgiou - Hormones, 2024 - Springer
Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease, with its incidence
increasing in parallel with the global prevalence of obesity and type 2 diabetes mellitus …