Oxygen-free radicals, more generally known as reactive oxygen species (ROS) along with
reactive nitrogen species (RNS) are well recognised for playing a dual role as both …

The amino-acid-derived polyamines have long been associated with cell growth and cancer,
and specific oncogenes and tumour-suppressor genes regulate polyamine metabolism …

Stem cells are proposed to continuously secrete trophic factors that potentially serve as
mediators of autocrine and paracrine activities, associated with reprogramming of the tumor …

Abstract The Oct3/4 gene, a POU family transcription factor, has been noted as being
specifically expressed in embryonic stem cells and in tumor cells but not in cells of …

The use of chemical compounds benefits society in a number of ways. Pesticides, for
instance, enable foodstuffs to be produced in sufficient quantities to satisfy the needs of …

Gap junctions are membrane structures made of intercellular channels which permit the
diffusion from cytoplasm to cytoplasm of small hydrophilic molecules. Nearly 40 years ago …

This review examines the vast catalytic and therapeutic potential offered by type I (ie oxygen-
insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with …

In recent years, stem cells have been the subject of increasing scientific interest because of
their utility in numerous biomedical applications. Stem cells are capable of renewing …

Abstract Octamer 4 (Oct4), a member of the POU family of transcription factors, plays a key
role in the maintenance of pluripotency and proliferation potential of embryonic stem cells …

Compared with transplanted tumor models or genetically engineered cancer models,
chemically induced primary malignancies in experimental animals can mimic the clinical …