Geroscience‐guided repurposing of FDA‐approved drugs to target aging: A proposed process and prioritization
AS Kulkarni, S Aleksic, DM Berger, F Sierra… - Aging …, 2022 - Wiley Online Library
Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …
declining function, independence, and quality of life. Geroscience‐guided approaches seek …
Regulatory updates and analytical methodologies for nitrosamine impurities detection in sartans, ranitidine, nizatidine, and metformin along with sample preparation …
KM Shaik, B Sarmah, GS Wadekar… - Critical reviews in …, 2022 - Taylor & Francis
Nitrosamine impurities have been detected in various pharmaceutical products in recent
days. Various sartans, ranitidine, nizatidine, and metformin have been recalled from the …
days. Various sartans, ranitidine, nizatidine, and metformin have been recalled from the …
Autophagy in metabolic syndrome: breaking the wheel by targeting the renin–angiotensin system
KR Menikdiwela, L Ramalingam, F Rasha… - Cell Death & …, 2020 - nature.com
Metabolic syndrome (MetS) is a complex, emerging epidemic which disrupts the metabolic
homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While …
homeostasis of several organs, including liver, heart, pancreas, and adipose tissue. While …
The renin-angiotensin-aldosterone system (RAAS) signaling pathways and cancer: foes versus allies
The renin-angiotensin-aldosterone system (RAAS), is an old system with new fundamental
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …
roles in cancer biology which influences cell growth, migration, death, and metastasis. RAAS …
Inflammation and NF-κB signaling in prostate cancer: Mechanisms and clinical implications
J Staal, R Beyaert - Cells, 2018 - mdpi.com
Prostate cancer is a highly prevalent form of cancer that is usually slow-developing and
benign. Due to its high prevalence, it is, however, still the second most common cause of …
benign. Due to its high prevalence, it is, however, still the second most common cause of …
The use of antihypertensive drugs as coadjuvant therapy in cancer
JA Carlos-Escalante, M de Jesus-Sanchez… - Frontiers in …, 2021 - frontiersin.org
Cancer is a complex group of diseases that constitute the second largest cause of mortality
worldwide. The development of new drugs for treating this disease is a long and costly …
worldwide. The development of new drugs for treating this disease is a long and costly …
The effect of local renin angiotensin system in the common types of cancer
The Renin Angiotensin System (RAS) is a hormonal system that is responsible for blood
pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it …
pressure hemostasis and electrolyte balance. It is implicated in cancer hallmarks because it …
Mechanobiology of autophagy: the unexplored side of cancer
MP Hernández-Cáceres, L Munoz, JM Pradenas… - Frontiers in …, 2021 - frontiersin.org
Proper execution of cellular function, maintenance of cellular homeostasis and cell survival
depend on functional integration of cellular processes and correct orchestration of cellular …
depend on functional integration of cellular processes and correct orchestration of cellular …
Inhibiting eukaryotic ribosome biogenesis
D Awad, M Prattes, L Kofler, I Rössler, M Loibl, M Pertl… - BMC biology, 2019 - Springer
Background Ribosome biogenesis is a central process in every growing cell. In eukaryotes,
it requires more than 250 non-ribosomal assembly factors, most of which are essential …
it requires more than 250 non-ribosomal assembly factors, most of which are essential …
Endothelial autophagy dysregulation in diabetes
Y Salemkour, O Lenoir - Cells, 2023 - mdpi.com
Diabetes mellitus is a major public health issue that affected 537 million people worldwide in
2021, a number that is only expected to increase in the upcoming decade. Diabetes is a …
2021, a number that is only expected to increase in the upcoming decade. Diabetes is a …