Discovery of novel small molecule inhibitors targeting progranulin-sortilin: A virtual high throughput screening approach
Introduction: Reduction in progranulin (PGRN) have been associated with various
neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane …
neurodegenerative diseases. PGRN binds with high affinity to sortilin (SORT), a membrane …
[PDF][PDF] AAV-GRN partially corrects motor deficits and ALS/FTLD-related pathology in
T Feng, G Minevich, P Liu, H Long, A Mitra, F Hu - researchgate.net
Loss of function of progranulin (PGRN), encoded by the granulin (GRN) gene, is implicated
in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are …
in several neurodegenerative diseases. Several therapeutics to boost PGRN levels are …
[PDF][PDF] Granulin Loss of Function in Human Mature Brain Organoids Implicates Astrocytes in TDP-43 Pathology
Loss of function (LoF) of Tar-binding protein 43 (TDP-43) and mislocalization, together with
TDP-43-positive and hyperphosphorylated inclusions, are found in postmortem tissue of …
TDP-43-positive and hyperphosphorylated inclusions, are found in postmortem tissue of …
[PDF][PDF] Progranulin maintains blood pressure and vascular tone dependent on EphrinA2 and Sortilin1 receptors and eNOS activation
TB do Nascimento - researchgate.net
Background: Even though vascular tone is an important determinant of blood pressure
management, the processes governing it are still not completely understood. Many …
management, the processes governing it are still not completely understood. Many …
[PDF][PDF] 急性心筋梗塞後病態におけるプログラニュリンの役割に関する研究
佐々木貴寛 - gifu-pu.repo.nii.ac.jp
序論虚血性心疾患は世界における死因の第 1 位であり, 世界総死亡者数の約 16% を占める (1).
虚血性心疾患の罹患者数は, 2020 年の時点で 2 億 4410 万人と推定されている (2). また …
虚血性心疾患の罹患者数は, 2020 年の時点で 2 億 4410 万人と推定されている (2). また …