Gene directed enzyme prodrug therapy (GDEPT) of cancer aims to improve the selectivity of
chemotherapy by gene transfer, thus enabling target cells to convert non-toxic prodrugs to …

Pancreatic cancer (PC) is a highly lethal disease and notoriously difficult to treat. Only a
small proportion of PC patients are eligible for surgical resection, whilst conventional …

Previous evidence suggested that the stress protein grp170 can function as a highly efficient
molecular chaperone, binding to large protein substrates and acting as a potent vaccine …

The outcomes for treatment of pancreatic cancer have not improved dramatically in many
decades. However, the recent promising results with combination chemotherapy regimens …

Background: To investigate pharmacokinetics and potency of antitumor activity of a novel 5‐
fluorouracil carrier erythrocyte (RBC‐FU) in mice bearing malignant ascites. Methods: RBC …

摘要目的: 探讨原癌基因Pokemon (POK erythroid myeloid ontogenic) 在大肠癌组织中的表达
及其与临床特征之间的关系. 方法: 采用逆转录酶聚合酶链反应(RT-PCR) 方法检测47 …

Background Transcription factor Pokemon, a central regulation gene of the important tumor
suppressor ARF gene, exerted its activity by acting upstream of many tumor-suppressing …

Abstract Background and Aim: The tumor‐suppressing role of Ras‐association domain
family 1A (RASSF1A) has been described in several systems. In this study, we tested its …

OBJECTIVE: To explore the exact mechanism of Pokemon in prostate cancer. MATERIALS
AND METHODS: Pokemon is a member of the POK family of transcriptional repressors. Its …

Background Cathespin-B (cath-B) is an important proteolytic enzyme involved in the disease
course of invasion in many types of cancer. Cath-B expression in subcutaneous …